mdkb midkine b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mdkbprovided by ZNC
Official Full Name: midkine bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010131-6
See related: Ensembl:ENSDARG00000020708 AllianceGenome:ZFIN:ZDB-GENE-010131-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mdk; mdk2; cb518; plei2; fb79b05; fj33b02; fj48a12; wu:fb79b05; wu:fj33b02; wu:fj48a12
Summary: Predicted to enable growth factor activity. Acts upstream of or within brain development; neural crest formation; and positive regulation of neuron differentiation. Located in extracellular region. Is expressed in several structures, including brain; neural keel; neural rod; neural tube; and retina. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (7872230..7880878)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (7748138..7756786)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of mdkb follows a daily rhythm, which is independent of the presence or absence of light.The spatial domain of mdkb expression within the inner nuclear layer expands during the night and contracts during the subjective day
Title: Midkine expression is regulated by the circadian clock in the retina of the zebrafish.
These data reveal that Mdka and Mdkb are signaling factors present in the retinal stem cell niches in both embryonic and mature retinas, and that their cellular expression is actively modulated during retinal development and regeneration.
Title: Cellular expression of midkine-a and midkine-b during retinal development and photoreceptor regeneration in zebrafish.
Results imply that Mdkb is required for the earliest steps of cell specification at the neural plate border in zebrafish.
Title: Midkine-b regulates cell specification at the neural plate border in zebrafish.
Ectopic ubiquitous expression of the mdkb gene in early zebrafish embryos causes completely distinct effects on neural crest and floorplate development.
Title: Functional divergence of two zebrafish midkine growth factors following fish-specific gene duplication.

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General gene information

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Markers

fj48a12.x1 (e-PCR)
- UniSTS:199430

AI558675 (e-PCR)
- UniSTS:206255

fj33b02.x1 (e-PCR)
- UniSTS:199096

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within neural crest formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: midkine b

Names: midkine-related growth factor b; pleiotrophin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.