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    sugt1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone [ Danio rerio (zebrafish) ]

    Gene ID: 492489, updated on 4-Jan-2025

    Summary

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    Official Symbol
    sugt1provided by ZNC
    Official Full Name
    SGT1 homolog, MIS12 kinetochore complex assembly cochaperoneprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-56
    See related
    Ensembl:ENSDARG00000100083 AllianceGenome:ZFIN:ZDB-GENE-041114-56
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sgut1; wu:fd45a02; zgc:103668
    Summary
    Predicted to enable protein-folding chaperone binding activity. Predicted to be located in cytoplasm. Orthologous to human SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See sugt1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (27977361..28019225)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (27283647..27325511)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B14 Neighboring gene uncharacterized LOC137495495 Neighboring gene uncharacterized LOC110439743 Neighboring gene carbohydrate sulfotransferase 10 Neighboring gene uncharacterized LOC137495496

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein SGT1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007361.1 → NP_001007362.1  protein SGT1 homolog

      See identical proteins and their annotated locations for NP_001007362.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085582
      UniProtKB/TrEMBL
      A7MCE7, Q5U3E4
      Related
      ENSDARP00000135565.1, ENSDART00000166819.2
      Conserved Domains (5) summary
      cd06489
      Location:135 → 218
      p23_CS_hSgt1_like; p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the ...
      PLN03088
      Location:10 → 322
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:33 → 63
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:34 → 65
      TPR_1; Tetratricopeptide repeat
      pfam05002
      Location:242 → 322
      SGS; SGS domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      27977361..28019225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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