mafbb v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bb [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mafbbprovided by ZNC
Official Full Name: v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bbprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010605-4
See related: Ensembl:ENSDARG00000070542 AllianceGenome:ZFIN:ZDB-GENE-010605-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: SMaf2; krml2; krml2.2
Summary: Enables sequence-specific DNA binding activity. Acts upstream of or within regulation of myeloid leukocyte differentiation and skeletal system development. Predicted to be active in nucleus. Is expressed in several structures, including immune system; mesoderm; nervous system; pleuroperitoneal region; and vein. Human ortholog(s) of this gene implicated in Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Orthologous to human MAFB (MAF bZIP transcription factor B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (25382602..25384213, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (25144986..25146597, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression.
Title: Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression.
These results indicate that MafA is the homologue of zebrafish SMaf1 and acts as a transcriptional activator of the insulin gene promoter through the RIPE3b element.
Title: Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bb

Names: Kreisler maf-related leucine zipper homolog 2.2; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B, duplicate b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131842.2 → NP_571917.2 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bb

See identical proteins and their annotated locations for NP_571917.2

Status: VALIDATED

Source sequence(s)

BC062823, EH498972

UniProtKB/TrEMBL

A0A286Y9N2, A0A8N7UZN9, Q6P5N3

Related

ENSDARP00000099244.2, ENSDART00000103650.5

Conserved Domains (3) summary

cd14718
Location:226 → 294

bZIP_Maf_large; coiled coil [structural motif]

pfam03131
Location:204 → 294

bZIP_Maf; bZIP Maf transcription factor

pfam08383
Location:77 → 114

Maf_N; Maf N-terminal region