U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    abca3b ATP-binding cassette, sub-family A (ABC1), member 3b [ Danio rerio (zebrafish) ]

    Gene ID: 564344, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    abca3bprovided by ZNC
    Official Full Name
    ATP-binding cassette, sub-family A (ABC1), member 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050517-2
    See related
    Ensembl:ENSDARG00000100524 AllianceGenome:ZFIN:ZDB-GENE-050517-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    abca3; si:ch211-155i15.6
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in swim bladder. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human ABCA3 (ATP binding cassette subfamily A member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See abca3b in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (12585634..12699904)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (12438910..12548455)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene vasorin b Neighboring gene uncharacterized LOC137490486 Neighboring gene cyclin F Neighboring gene uncharacterized LOC108182802 Neighboring gene cytochrome P450, family 2, subfamily K, polypeptide 18 Neighboring gene cytochrome P450, family 2, subfamily k, polypeptide 20

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Gene expression profiles in zebrafish (Danio rerio) liver after acute exposure to okadaic acid. Zhang NS, et al. Environ Toxicol Pharmacol, 2014 Mar. PMID 24637248
    2. Microcystin-LR-regulated transcriptome dynamics in ZFL cells. Lu X, et al. Aquat Toxicol, 2019 Jul. PMID 31136897
    3. Development of the Swimbladder Surfactant System and Biogenesis of Lysosome-Related Organelles Is Regulated by BLOS1 in Zebrafish. Chen T, et al. Genetics, 2018 Mar. PMID 29339408, Free PMC Article
    4. Atp7b deficiency induces zebrafish eye developmental defects. Wu Y, et al. Metallomics, 2023 May 2. PMID 37070960
    5. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Annilo T, et al. Genomics, 2006 Jul. PMID 16631343

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ATP-binding cassette sub-family A member 3; phospholipid-transporting ATPase ABCA3
    Names
    ATP-binding cassette, sub-family A (ABC1), member 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      12585634..12699904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473111.2 → XP_021328786.1  phospholipid-transporting ATPase ABCA3

      UniProtKB/TrEMBL
      A0A0R4ISK5, A0A8M9Q293
      Conserved Domains (1) summary
      cl28181
      Location:122 → 1695
      AAA; ATPases associated with a variety of cellular activities

    2. XM_021473114.2 → XP_021328789.1  phospholipid-transporting ATPase ABCA3

      UniProtKB/TrEMBL
      A0A0R4ISK5, A0A8M9Q293
      Conserved Domains (1) summary
      cl28181
      Location:122 → 1695
      AAA; ATPases associated with a variety of cellular activities

    3. XM_068218749.1 → XP_068074850.1  phospholipid-transporting ATPase ABCA3

      UniProtKB/TrEMBL
      A0A0R4ISK5, A0A8M9Q293

    4. XM_009299214.4 → XP_009297489.1  phospholipid-transporting ATPase ABCA3

      See identical proteins and their annotated locations for XP_009297489.1

      UniProtKB/TrEMBL
      A0A0R4ISK5, A0A8M9Q293
      Related
      ENSDARP00000137256.1, ENSDART00000159252.3
      Conserved Domains (1) summary
      cl28181
      Location:122 → 1695
      AAA; ATPases associated with a variety of cellular activities
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools