hnf4g hepatocyte nuclear factor 4, gamma [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hnf4gprovided by ZNC
Official Full Name: hepatocyte nuclear factor 4, gammaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060929-100
See related: Ensembl:ENSDARG00000071565 AllianceGenome:ZFIN:ZDB-GENE-060929-100
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hnf4gamma; zgc:153265
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human HNF4G (hepatocyte nuclear factor 4 gamma). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (23647786..23675446, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (23502612..23530294, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conserved roles for Hnf4 family transcription factors in zebrafish development and intestinal function.
Title: Conserved roles for Hnf4 family transcription factors in zebrafish development and intestinal function.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hepatocyte nuclear factor 4-gamma

Names: NR2A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001075111.2 → NP_001068579.2 hepatocyte nuclear factor 4-gamma isoform 1

Status: VALIDATED

Source sequence(s)

BX640462, CF996633, EH501708

UniProtKB/TrEMBL

A0A8M1NAU2, F1QM73

Related

ENSDARP00000120982.1, ENSDART00000144193.3
NM_001331156.1 → NP_001318085.1 hepatocyte nuclear factor 4-gamma isoform 2

Status: VALIDATED

Source sequence(s)

BX640462

UniProtKB/TrEMBL

A0A8M1P4A1, F1RCC7

Related

ENSDARP00000066643.6, ENSDART00000066644.8

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

23647786..23675446 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017353837.3 → XP_017209326.1 hepatocyte nuclear factor 4-gamma isoform X2

UniProtKB/TrEMBL

A0A8M6YY37
XM_021470189.2 → XP_021325864.1 hepatocyte nuclear factor 4-gamma isoform X1

UniProtKB/TrEMBL

A0A0R4IJK6, A0A8M9PLU8

Related

ENSDARP00000134134.2, ENSDART00000164750.3

Conserved Domains (2) summary

cd06931
Location:154 → 375

NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes

cd06960
Location:62 → 137

NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers