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    hoxb10a homeobox B10a [ Danio rerio (zebrafish) ]

    Gene ID: 58056, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hoxb10aprovided by ZNC
    Official Full Name
    homeobox B10aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000328-2
    See related
    AllianceGenome:ZFIN:ZDB-GENE-000328-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    z-122; hoxb10; im:7139959; wu:fc25g03
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in CNS interneuron; central nervous system; margin; neural tube; and spinal cord. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hoxb10a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (23668824..23672137)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (23538276..23541589)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490577 Neighboring gene uncharacterized LOC103910246 Neighboring gene homeobox B13a Neighboring gene even-skipped-like1 Neighboring gene microRNA 196b Neighboring gene homeobox B9a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Nodal-related signals establish mesendodermal fate and trunk neural identity in zebrafish. Feldman B, et al. Curr Biol, 2000 May 4. PMID 10801442
    2. miR-196 regulates axial patterning and pectoral appendage initiation. He X, et al. Dev Biol, 2011 Sep 15. PMID 21787766, Free PMC Article
    3. Spatiotemporal analysis of zebrafish hox gene regulation by Cdx4. Hayward AG 2nd, et al. Dev Dyn, 2015 Dec. PMID 26335559
    4. Tbx16 regulates hox gene activation in mesodermal progenitor cells. Payumo AY, et al. Nat Chem Biol, 2016 Sep. PMID 27376691, Free PMC Article
    5. An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Yamada K, et al. Development, 2021 Jun 1. PMID 34096572

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Hox-B10a
    Names
    homeo box B10a
    homeobox gene B-10
    hox-B10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131541.1 → NP_571616.1  homeobox protein Hox-B10a

      Status: VALIDATED

      Source sequence(s)
      BX927395
      UniProtKB/Swiss-Prot
      A9JTD5, B3DK18, O57361, Q9PWL7
      UniProtKB/TrEMBL
      A0A8M1P5T9
      Conserved Domains (1) summary
      pfam00046
      Location:209 → 262
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      23668824..23672137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9PWL7.2 GenPept UniProtKB/Swiss-Prot:Q9PWL7

    Gene LinkOut

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