sh3gl1b SH3-domain GRB2-like 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sh3gl1bprovided by ZNC
Official Full Name: SH3-domain GRB2-like 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031001-6
See related: Ensembl:ENSDARG00000002642 AllianceGenome:ZFIN:ZDB-GENE-031001-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb831; sh3gl1
Summary: Predicted to be involved in synaptic vesicle uncoating. Predicted to be located in cell projection; early endosome membrane; and podosome. Predicted to be active in cytoplasm; glutamatergic synapse; and presynapse. Is expressed in several structures, including cardiovascular system; mesoderm; musculature system; nervous system; and neural tube. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (18840704..18879846, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (18810608..18849483, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in synaptic vesicle uncoating	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in podosome	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SH3-domain GRB2-like 1b

Names: SH3-domain GRB2-like 1; eena

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201497.1 → NP_958905.1 SH3-domain GRB2-like 1b

See identical proteins and their annotated locations for NP_958905.1

Status: PROVISIONAL

Source sequence(s)

BC045942

UniProtKB/TrEMBL

B2GP10, Q7ZVA3

Related

ENSDARP00000091264.4, ENSDART00000100491.6

Conserved Domains (2) summary

cd07592
Location:25 → 247

BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A

cd11803
Location:293 → 346

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

18840704..18879846 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166793.4 → XP_005166850.1 SH3-domain GRB2-like 1b isoform X3

UniProtKB/TrEMBL

A0A8M2BE91

Conserved Domains (2) summary

cd07592
Location:25 → 247

BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A

cd11803
Location:292 → 345

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
XM_009303889.3 → XP_009302164.1 SH3-domain GRB2-like 1b isoform X2

UniProtKB/TrEMBL

A0A8M3BBQ5

Conserved Domains (2) summary

cd07592
Location:25 → 247

BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A

cd11803
Location:308 → 361

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
XM_021478204.2 → XP_021333879.1 SH3-domain GRB2-like 1b isoform X1

UniProtKB/TrEMBL

A0A0R4IGE6, A0A8M9Q9K3

Related

ENSDARP00000133533.1, ENSDART00000169043.2

Conserved Domains (2) summary

cd07592
Location:25 → 247

BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A

cd11803
Location:309 → 362

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A