lgals3b lectin, galactoside binding soluble 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lgals3bprovided by ZNC
Official Full Name: lectin, galactoside binding soluble 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4324
See related: Ensembl:ENSDARG00000044001 AllianceGenome:ZFIN:ZDB-GENE-030131-4324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Drgal3; fc90g02; lgals3l; wu:fc90g02; zgc:123117
Summary: Predicted to enable several functions, including IgE binding activity; galactoside binding activity; and laminin binding activity. Predicted to be involved in several processes, including leukocyte chemotaxis; negative regulation of extrinsic apoptotic signaling pathway; and positive regulation of calcium ion import. Predicted to be active in several cellular components, including extracellular space; immunological synapse; and nucleus. Is expressed in several structures, including digestive system; eye; mesoderm; ovary; and spleen. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (10824659..10838431, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (10668625..10682374, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fb17c01.x1 (e-PCR)
- UniSTS:190208

AA658802 (e-PCR)
- UniSTS:206857

fb14d12.x1 (e-PCR)
- UniSTS:202926

fb17c01.x1 (e-PCR)
- UniSTS:190207

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables IgE binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables disaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables galactoside binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables laminin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monocyte chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of calcium ion import	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in immunological synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: galectin-3b

Names: chimera galectin Gal3; lectin, galactoside-binding, soluble, 3 (galectin 3)-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.