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    ank2b ankyrin 2b, neuronal [ Danio rerio (zebrafish) ]

    Gene ID: 450043, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ank2bprovided by ZNC
    Official Full Name
    ankyrin 2b, neuronalprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-165
    See related
    Ensembl:ENSDARG00000043313 AllianceGenome:ZFIN:ZDB-GENE-041010-165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ank2; zgc:101738
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in protein localization to T-tubule; protein localization to ciliary inversin compartment; and regulation of cardiac muscle contraction. Predicted to act upstream of or within proteolysis and signal transduction. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in T-tubule and cilium. Is expressed in central nervous system; cranial ganglion; optic vesicle; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ank2b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (57886100..58130736, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (57686215..57796505, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene arylsulfatase family, member J Neighboring gene calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 Neighboring gene neutral sphingomyelinase (N-SMase) activation associated factor Neighboring gene un-named hu7910 Neighboring gene gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Interaction of infectious spleen and kidney necrosis virus ORF119L with PINCH leads to dominant-negative inhibition of integrin-linked kinase and cardiovascular defects in zebrafish. Yuan JM, et al. J Virol, 2015 Jan. PMID 25355883, Free PMC Article
    2. Patterns of alternative splicing in response to cold acclimation in fish. Healy TM, et al. J Exp Biol, 2019 Mar 7. PMID 30692167
    3. Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Thomas-Jinu S, et al. Neuron, 2017 Apr 19. PMID 28392072, Free PMC Article
    4. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin-2b
    Names
    ankyrin 2, neuronal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346207.1 → NP_001333136.1  ankyrin-2b isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX901910, CR354563
      UniProtKB/TrEMBL
      A0A8M1PAL4
      Related
      ENSDARP00000140874.2, ENSDART00000172082.2

    2. NM_001430834.1 → NP_001417763.1  ankyrin-2b isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX901910, CR354563
      UniProtKB/TrEMBL
      A0A8M9QBW8

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      57886100..58130736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222254.1 → XP_068078355.1  ankyrin-2b isoform X12

      UniProtKB/TrEMBL
      A0A8M9QGV2

    2. XM_068222252.1 → XP_068078353.1  ankyrin-2b isoform X9

      UniProtKB/TrEMBL
      A0A8M9Q1F7

    3. XM_068222257.1 → XP_068078358.1  ankyrin-2b isoform X15

      UniProtKB/TrEMBL
      A0A8M9Q7R2

    4. XM_068222267.1 → XP_068078368.1  ankyrin-2b isoform X29

    5. XM_021477510.2 → XP_021333185.1  ankyrin-2b isoform X44

      UniProtKB/TrEMBL
      A0A8M9QGY1
      Conserved Domains (5) summary
      smart00218
      Location:962 → 1066
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:234 → 359
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:1436 → 1519
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:470 → 501
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:407 → 458
      Ank_4; Ankyrin repeats (many copies)

    6. XM_068222263.1 → XP_068078364.1  ankyrin-2b isoform X25

    7. XM_021477488.2 → XP_021333163.1  ankyrin-2b isoform X18

      UniProtKB/TrEMBL
      A0A8M9Q1G4
      Conserved Domains (7) summary
      smart00218
      Location:978 → 1115
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:234 → 359
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:3128 → 3211
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:470 → 501
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:407 → 458
      Ank_4; Ankyrin repeats (many copies)
      cl25751
      Location:2855 → 3268
      DUF4045; Domain of unknown function (DUF4045)
      cl26511
      Location:1558 → 1854
      Neuromodulin_N; Gap junction protein N-terminal region

    8. XM_021477482.2 → XP_021333157.1  ankyrin-2b isoform X11

      UniProtKB/TrEMBL
      A0A8M9PNT0
      Conserved Domains (7) summary
      smart00218
      Location:996 → 1133
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:234 → 359
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:3146 → 3229
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:470 → 501
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:407 → 458
      Ank_4; Ankyrin repeats (many copies)
      cl25751
      Location:2873 → 3286
      DUF4045; Domain of unknown function (DUF4045)
      cl26511
      Location:1576 → 1872
      Neuromodulin_N; Gap junction protein N-terminal region

    9. XM_068222248.1 → XP_068078349.1  ankyrin-2b isoform X4

    10. XM_068222266.1 → XP_068078367.1  ankyrin-2b isoform X28

      UniProtKB/TrEMBL
      A0A8M9PNT8

    11. XM_068222264.1 → XP_068078365.1  ankyrin-2b isoform X26

      UniProtKB/TrEMBL
      A0A8M9QGV9

    12. XM_068222260.1 → XP_068078361.1  ankyrin-2b isoform X20

      UniProtKB/TrEMBL
      A0A8M9Q7Q0

    13. XM_021477493.2 → XP_021333168.1  ankyrin-2b isoform X24

      UniProtKB/TrEMBL
      A0A8M9PNT8, A0A8M9Q1H0
      Conserved Domains (7) summary
      smart00218
      Location:970 → 1074
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242 → 367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:3087 → 3170
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:478 → 509
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:415 → 466
      Ank_4; Ankyrin repeats (many copies)
      cl25751
      Location:2814 → 3227
      DUF4045; Domain of unknown function (DUF4045)
      cl26511
      Location:1517 → 1813
      Neuromodulin_N; Gap junction protein N-terminal region

    14. XM_021477491.2 → XP_021333166.1  ankyrin-2b isoform X21

      UniProtKB/TrEMBL
      A0A8M9Q7Q0, A0A8M9QBW2
      Related
      ENSDARP00000114785.1, ENSDART00000147287.3
      Conserved Domains (7) summary
      smart00218
      Location:970 → 1107
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242 → 367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:3120 → 3203
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:478 → 509
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:415 → 466
      Ank_4; Ankyrin repeats (many copies)
      cl25751
      Location:2847 → 3260
      DUF4045; Domain of unknown function (DUF4045)
      cl26511
      Location:1550 → 1846
      Neuromodulin_N; Gap junction protein N-terminal region

    15. XM_021477486.2 → XP_021333161.1  ankyrin-2b isoform X17

      UniProtKB/TrEMBL
      A0A8M9Q7Q0, A0A8M9QBV6
      Conserved Domains (7) summary
      smart00218
      Location:982 → 1119
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242 → 367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:3132 → 3215
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:478 → 509
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:415 → 466
      Ank_4; Ankyrin repeats (many copies)
      cl25751
      Location:2859 → 3272
      DUF4045; Domain of unknown function (DUF4045)
      cl26511
      Location:1562 → 1858
      Neuromodulin_N; Gap junction protein N-terminal region

    16. XM_068222256.1 → XP_068078357.1  ankyrin-2b isoform X14

      UniProtKB/TrEMBL
      A0A8M9Q7Q0

    17. XM_068222251.1 → XP_068078352.1  ankyrin-2b isoform X8

      UniProtKB/TrEMBL
      A0A8M9Q7Q0

    18. XM_068222262.1 → XP_068078363.1  ankyrin-2b isoform X23

      UniProtKB/TrEMBL
      A0A8M9PNT4

    19. XM_021477475.2 → XP_021333150.1  ankyrin-2b isoform X6

      UniProtKB/TrEMBL
      A0A8M9Q1E3, A0A8M9QGU1
      Conserved Domains (7) summary
      smart00218
      Location:1005 → 1142
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242 → 367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:3155 → 3238
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:478 → 509
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:415 → 466
      Ank_4; Ankyrin repeats (many copies)
      cl25751
      Location:2882 → 3295
      DUF4045; Domain of unknown function (DUF4045)
      cl26511
      Location:1585 → 1881
      Neuromodulin_N; Gap junction protein N-terminal region

    20. XM_068222261.1 → XP_068078362.1  ankyrin-2b isoform X22

      UniProtKB/TrEMBL
      A0A8M9QGV9

    21. XM_068222253.1 → XP_068078354.1  ankyrin-2b isoform X10

      UniProtKB/TrEMBL
      A0A8M9Q7Q9

    22. XM_068222246.1 → XP_068078347.1  ankyrin-2b isoform X2

      UniProtKB/TrEMBL
      A0A8M9PNS3

    23. XM_068222259.1 → XP_068078360.1  ankyrin-2b isoform X19

      UniProtKB/TrEMBL
      A0A8M9PNT8

    24. XM_068222250.1 → XP_068078351.1  ankyrin-2b isoform X7

      UniProtKB/TrEMBL
      A0A8M9QBV0

    25. XM_068222258.1 → XP_068078359.1  ankyrin-2b isoform X16

      UniProtKB/TrEMBL
      A0A8M9QGV9

    26. XM_068222281.1 → XP_068078382.1  ankyrin-2b isoform X43

      UniProtKB/TrEMBL
      A0A8M9Q7T1

    27. XM_068222279.1 → XP_068078380.1  ankyrin-2b isoform X41

      UniProtKB/TrEMBL
      A0A8M9QBY0

    28. XM_068222278.1 → XP_068078379.1  ankyrin-2b isoform X40

      UniProtKB/TrEMBL
      A0A8M9QGX6

    29. XM_068222249.1 → XP_068078350.1  ankyrin-2b isoform X5

      UniProtKB/TrEMBL
      A0A8M9QGU6

    30. XM_068222280.1 → XP_068078381.1  ankyrin-2b isoform X42

      UniProtKB/TrEMBL
      A0A8M9Q1I9

    31. XM_068222277.1 → XP_068078378.1  ankyrin-2b isoform X39

      UniProtKB/TrEMBL
      A0A8M9Q7S6

    32. XM_068222276.1 → XP_068078377.1  ankyrin-2b isoform X38

      UniProtKB/TrEMBL
      A0A8M9Q1I2

    33. XM_068222274.1 → XP_068078375.1  ankyrin-2b isoform X36

      UniProtKB/TrEMBL
      A0A8M9QBX3

    34. XM_068222273.1 → XP_068078374.1  ankyrin-2b isoform X35

      UniProtKB/TrEMBL
      A0A8M9QGX0

    35. XM_068222275.1 → XP_068078376.1  ankyrin-2b isoform X37

      UniProtKB/TrEMBL
      A0A8M9PNU7

    36. XM_068222272.1 → XP_068078373.1  ankyrin-2b isoform X34

      UniProtKB/TrEMBL
      A0A8M9Q7S2

    37. XM_068222271.1 → XP_068078372.1  ankyrin-2b isoform X33

      UniProtKB/TrEMBL
      A0A8M9Q1H7

    38. XM_068222270.1 → XP_068078371.1  ankyrin-2b isoform X32

      UniProtKB/TrEMBL
      A0A8M9PNU3

    39. XM_068222268.1 → XP_068078369.1  ankyrin-2b isoform X30

      UniProtKB/TrEMBL
      A0A8M9QGW4

    40. XM_068222269.1 → XP_068078370.1  ankyrin-2b isoform X31

      UniProtKB/TrEMBL
      A0A8M9QBW8

    41. XM_068222255.1 → XP_068078356.1  ankyrin-2b isoform X13

      UniProtKB/TrEMBL
      A0A8M9PNT4

    42. XM_068222265.1 → XP_068078366.1  ankyrin-2b isoform X27

      UniProtKB/TrEMBL
      A0A8M9Q7R7

    43. XM_068222245.1 → XP_068078346.1  ankyrin-2b isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q1E3

    44. XM_068222247.1 → XP_068078348.1  ankyrin-2b isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q1F0

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001006063.2: Suppressed sequence

      Description
      NM_001006063.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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