trappc11 trafficking protein particle complex subunit 11 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trappc11provided by ZNC
Official Full Name: trafficking protein particle complex subunit 11provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1723
See related: Ensembl:ENSDARG00000004726 AllianceGenome:ZFIN:ZDB-GENE-030131-1723
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fgr; foigr; c4orf41; fb78g05; flj12716l; zgc:63684; wu:fb78g05; zgc:136723
Summary: Acts upstream of or within several processes, including liver development; protein N-linked glycosylation; and protein secretion. Predicted to be located in Golgi apparatus. Used to study steatotic liver disease. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2S. Orthologous to human TRAPPC11 (trafficking protein particle complex subunit 11). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (7320948..7375028, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (7014537..7068674, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAPPC11 role in protein glycosylation and lipid-linked oligosaccharides biosynthesis
Title: trappc11 is required for protein glycosylation in zebrafish and humans.
fois gras mutation develops large, lipid-filled hepatocytes, resembling those in individuals with fatty liver disease
Title: A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease.

Submit: New GeneRIF Correction

General gene information

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Markers

fc16h02.y1 (e-PCR)
- UniSTS:192817

fb19f05.y1 (e-PCR)
- UniSTS:190264

fb78g05.x1 (e-PCR)
- UniSTS:191448

fb78g05.x1 (e-PCR)
- UniSTS:191449

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein N-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of response to endoplasmic reticulum stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trafficking protein particle complex subunit 11

Names: FLJ12716-like protein; foie gras; protein foie gras; trafficking protein particle complex 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199626.2 → NP_955920.2 trafficking protein particle complex subunit 11

See identical proteins and their annotated locations for NP_955920.2

Status: PROVISIONAL

Source sequence(s)

AY648743

UniProtKB/Swiss-Prot

Q1RLX4

Related

ENSDARP00000054808.4, ENSDART00000054809.6

Conserved Domains (2) summary

pfam11817
Location:263 → 522

Foie-gras_1; Foie gras liver health family 1

pfam12742
Location:1036 → 1095

Gryzun-like; Gryzun, putative Golgi trafficking

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

7320948..7375028 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157122.5 → XP_005157179.1 trafficking protein particle complex subunit 11 isoform X1

See identical proteins and their annotated locations for XP_005157179.1

UniProtKB/Swiss-Prot

Q1RLX4, Q6DRL6, Q6PGX1

Conserved Domains (2) summary

pfam11817
Location:263 → 522

Foie-gras_1; Foie gras liver health family 1

pfam12742
Location:1036 → 1095

Gryzun-like; Gryzun, putative Golgi trafficking