capzb capping actin protein of muscle Z-line subunit beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: capzbprovided by ZNC
Official Full Name: capping actin protein of muscle Z-line subunit betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7023
See related: Ensembl:ENSDARG00000100252 AllianceGenome:ZFIN:ZDB-GENE-030131-7023
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66149; wu:fk65f06
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within muscle cell development and neural crest cell migration. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of F-actin capping protein complex. Is expressed in fin bud; head; pharyngeal arch; and somite. Used to study cleft palate. Orthologous to human CAPZB (capping actin protein of muscle Z-line subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (396629..411299)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (97130..111800, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proper capzb dosage is important during craniofacial embryogenesis, and regulates both cell behavior and tissue morphogenesis. Loss of capzb affects cell morphology, differentiation and neural crest migration. Differentiation of both myogenic stem cells and neural crest cells requires capzb. During palate morphogenesis, defective cranial neural crest cell migration in capzb(-/-) mutants results in a cleft phenotype.
Title: Actin capping protein CAPZB regulates cell morphology, differentiation, and neural crest migration in craniofacial morphogenesis†.

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General gene information

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Markers

fb76g04.x1 (e-PCR)
- UniSTS:191318

fb76g04.x1 (e-PCR)
- UniSTS:191319

fk65f06.x1 (e-PCR)
- UniSTS:201377

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin filament capping	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within barbed-end actin filament capping	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F-actin-capping protein subunit beta

Names: capping protein (actin filament) muscle Z-line, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199935.1 → NP_956229.1 F-actin-capping protein subunit beta

See identical proteins and their annotated locations for NP_956229.1

Status: PROVISIONAL

Source sequence(s)

BC055514

UniProtKB/TrEMBL

A0A8M3ALX5, Q7SXP1

Conserved Domains (1) summary

pfam01115
Location:11 → 239

F_actin_cap_B; F-actin capping protein, beta subunit

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

396629..411299

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009295746.4 → XP_009294021.1 F-actin-capping protein subunit beta isoform X2

See identical proteins and their annotated locations for XP_009294021.1

UniProtKB/TrEMBL

A0A8M3ALX5, Q7SXP1

Related

ENSDARP00000140899.1, ENSDART00000163198.2

Conserved Domains (1) summary

pfam01115
Location:11 → 239

F_actin_cap_B; F-actin capping protein, beta subunit
XM_009295745.3 → XP_009294020.1 F-actin-capping protein subunit beta isoform X1

UniProtKB/TrEMBL

A0A8M3AUB3

Conserved Domains (1) summary

pfam01115
Location:11 → 239

F_actin_cap_B; F-actin capping protein, beta subunit