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    nfe2 nuclear factor, erythroid 2 [ Danio rerio (zebrafish) ]

    Gene ID: 317765, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nfe2provided by ZNC
    Official Full Name
    nuclear factor, erythroid 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030124-1
    See related
    Ensembl:ENSDARG00000020606 AllianceGenome:ZFIN:ZDB-GENE-030124-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Enables protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Acts upstream of or within several processes, including otic vesicle morphogenesis; regulation of primitive erythrocyte differentiation; and swim bladder inflation. Part of transcription regulator complex. Is expressed in blood; otic placode; otic vesicle; ventral mesenchyme; and ventral mesoderm. Orthologous to human NFE2 (nuclear factor, erythroid 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nfe2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (36311494..36320701, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (36212127..36222031, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene chromobox homolog 5 (HP1 alpha homolog, Drosophila) Neighboring gene heterogeneous nuclear ribonucleoprotein A1b Neighboring gene COPI coat complex subunit zeta 1 Neighboring gene zinc finger protein 740b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Rost MS, et al. Blood Adv, 2018 Dec 11. PMID 30504234, Free PMC Article
    2. Establishment of a Bernard-Soulier syndrome model in zebrafish. Lin Q, et al. Haematologica, 2022 Jul 1. PMID 34407604, Free PMC Article
    3. Loss of fibrinogen in zebrafish results in an asymptomatic embryonic hemostatic defect and synthetic lethality with thrombocytopenia. Hu Z, et al. J Thromb Haemost, 2019 Apr. PMID 30663848, Free PMC Article
    4. Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets. Ramsden R, et al. Redox Biol, 2016 Oct. PMID 27470083, Free PMC Article
    5. Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish. Yang L, et al. J Thromb Haemost, 2022 Aug. PMID 35622056

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within otic vesicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IC
    Inferred by Curator
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of primitive erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within swim bladder inflation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor NF-E2 45 kDa subunit
    Names
    nuclear factor (erythroid-derived 2), 45 kDa
    nuclear factor protein
    nuclear factor, erythroid-derived 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175043.2 → NP_778208.1  transcription factor NF-E2 45 kDa subunit

      See identical proteins and their annotated locations for NP_778208.1

      Status: PROVISIONAL

      Source sequence(s)
      AY170917
      UniProtKB/TrEMBL
      Q7ZZR2
      Related
      ENSDARP00000105608.2, ENSDART00000125860.3
      Conserved Domains (1) summary
      cd14720
      Location:310 → 377
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      36311494..36320701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216670.1 → XP_068072771.1  transcription factor NF-E2 45 kDa subunit isoform X1

      UniProtKB/TrEMBL
      A0A8M2B990, F1QWY1

    2. XM_009297037.4 → XP_009295312.1  transcription factor NF-E2 45 kDa subunit isoform X1

      See identical proteins and their annotated locations for XP_009295312.1

      UniProtKB/TrEMBL
      A0A8M2B990, F1QWY1
      Related
      ENSDARP00000002745.4, ENSDART00000014840.6
      Conserved Domains (1) summary
      cd14720
      Location:357 → 424
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    3. XM_005162369.5 → XP_005162426.1  transcription factor NF-E2 45 kDa subunit isoform X1

      See identical proteins and their annotated locations for XP_005162426.1

      UniProtKB/TrEMBL
      A0A8M2B990, F1QWY1
      Conserved Domains (1) summary
      cd14720
      Location:357 → 424
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version

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