atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp2a1provided by ZNC
Official Full Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-020905-1
See related: Ensembl:ENSDARG00000020574 AllianceGenome:ZFIN:ZDB-GENE-020905-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb279; serca; serca1; zgc:92110; wu:cegs655; wu:fb17h11; wu:fb19b10
Summary: Predicted to enable P-type calcium transporter activity. Acts upstream of or within several processes, including intracellular calcium ion homeostasis; negative regulation of muscle contraction; and relaxation of skeletal muscle. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in several structures, including digestive system; eye; mesoderm; musculature system; and pectoral fin. Used to study Brody myopathy. Human ortholog(s) of this gene implicated in Brody myopathy. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 3

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (26145034..26154478)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (26014163..26023607)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The different forms of phospholamban in zebrafish may provide a novel SERCA regulatory mechanism.
Title: Regulation of the sarcoplasmic reticulum calcium pump by divergent phospholamban isoforms in zebrafish.
study showed that accordian acc(dta5) mutants harbor a novel mutation in atp2a1; indicate the acc(dta5) mutation diminishes SERCA1 function to a greater degree than other acc alleles through haploinsufficient or dominant-negative molecular mechanisms
Title: Analysis of a zebrafish behavioral mutant reveals a dominant mutation in atp2a1/SERCA1.
encodes the sarco(endo)plasmic reticulum Ca2+-ATPase 1 (SERCA1), a Ca2+ pump found in the muscle sarcoplasmic reticulum (SR) that is responsible for pumping Ca2+ from the cytosol back to the SR
Title: accordion, a zebrafish behavioral mutant, has a muscle relaxation defect due to a mutation in the ATPase Ca2+ pump SERCA1.
concluded that the motility dysfunction in embryonic and larval accordion zebrafish stems directly from defective calcium transport in skeletal muscle due to mutation in SERCA rather than defective CNS drive.
Title: A mutation in serca underlies motility dysfunction in accordion zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fb19b10.x1 (e-PCR)
- UniSTS:203029

STS49.D01.01 (e-PCR)
- UniSTS:205705

fb17h11.x1 (e-PCR)
- UniSTS:202997

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within relaxation of skeletal muscle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Names: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; acc; accordion; sarcoendoplasmic reticulum calcium ATPase

NP_001007030.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007029.1 → NP_001007030.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 1

See identical proteins and their annotated locations for NP_001007030.1

Status: PROVISIONAL

Source sequence(s)

AB178533

UniProtKB/TrEMBL

F6NLB7, Q5W924, Q642Z0

Related

ENSDARP00000135633.1, ENSDART00000162546.3

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:93 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)