amfra autocrine motility factor receptor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: amfraprovided by ZNC
Official Full Name: autocrine motility factor receptor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2190
See related: Ensembl:ENSDARG00000020218 AllianceGenome:ZFIN:ZDB-GENE-040426-2190
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: amfr; gp78; zgc:63893; wu:fi06e06; wu:fi37e05
Summary: Enables ubiquitin protein ligase activity. Acts upstream of or within protein polyubiquitination and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane. Is expressed in brain; digestive system; eye; heart; and muscle. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 89. Orthologous to human AMFR (autocrine motility factor receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 25

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (36197733..36218023, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (35648014..35668320, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gp78 plays a critical role in protecting against ER stress in liver
Title: The E3 ubiquitin ligase gp78 protects against ER stress in zebrafish liver.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K48-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: E3 ubiquitin-protein ligase AMFR

Names: AMF receptor; autocrine motility factor receptor, E3 ubiquitin protein ligase a

NP_998328.2

EC 2.3.2.36

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213163.2 → NP_998328.2 E3 ubiquitin-protein ligase AMFR

Status: VALIDATED

Source sequence(s)

CU855766

UniProtKB/Swiss-Prot

A0A8M3AWU0, F1QB30, Q6PFU8

Related

ENSDARP00000106624.2, ENSDART00000122559.4

Conserved Domains (3) summary

cd14421
Location:451 → 491

CUE_AMFR; CUE domain found in autocrine motility factor receptor (AMFR) and similar proteins

cd16455
Location:332 → 375

RING-H2_AMFR; RING finger, H2 subclass, found in autocrine motility factor receptor (AMFR) and similar proteins

cl26329
Location:79 → 375

zf-rbx1; RING-H2 zinc finger domain