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    faf1 Fas (TNFRSF6) associated factor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406243, updated on 9-Dec-2024

    Summary

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    Official Symbol
    faf1provided by ZNC
    Official Full Name
    Fas (TNFRSF6) associated factor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2863
    See related
    Ensembl:ENSDARG00000022418 AllianceGenome:ZFIN:ZDB-GENE-040426-2863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc25h12; zgc:55752; wu:fc25h12
    Summary
    Predicted to enable NF-kappaB binding activity and ubiquitin binding activity. Acts upstream of or within cartilage development; fin regeneration; and pharyngeal system development. Predicted to be active in endoplasmic reticulum and nucleus. Is expressed in pharyngeal arch; pharyngeal arch 1; pharyngeal arch 2; and pharyngeal arch 3-7. Orthologous to human FAF1 (Fas associated factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See faf1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (16273966..16406501, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (16239064..16370789, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene ELAV like neuron-specific RNA binding protein 4 Neighboring gene DMRT-like family A2 Neighboring gene cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) Neighboring gene ring finger protein 11b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. FAF1, a gene that is disrupted in cleft palate and has conserved function in zebrafish. Ghassibe-Sabbagh M, et al. Am J Hum Genet, 2011 Feb 11. PMID 21295280, Free PMC Article
    2. Zebrafish dmrta2 regulates the expression of cdkn2c in spermatogenesis in the adult testis. Xu S, et al. Biol Reprod, 2013 Jan. PMID 23175770
    3. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NF-kappaB binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fin regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pharyngeal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FAS-associated factor 1
    Names
    Fas associated factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212973.2 → NP_998138.2  FAS-associated factor 1

      Status: VALIDATED

      Source sequence(s)
      CN512998, CR388216, CU467870, DR723806
      UniProtKB/TrEMBL
      A0A8M1PMZ0, B0UXY9
      Related
      ENSDARP00000037156.4, ENSDART00000034004.6
      Conserved Domains (4) summary
      cd01769
      Location:134 → 196
      UBL; Ubiquitin-like domain of UBL
      cd01771
      Location:595 → 674
      Faf1_UBX; Faf1 UBX domain
      cd02990
      Location:377 → 512
      UAS_FAF1; UAS family, FAS-associated factor 1 (FAF1) subfamily; FAF1 contains a UAS domain of unknown function N-terminal to a ubiquitin-associated UBX domain. FAF1 also contains ubiquitin-associated UBA and nuclear targeting domains, N-terminal to the UAS domain. ...
      cd14413
      Location:16 → 48
      UBA_FAF1; UBA-like domain found in FAS-associated factor 1 (FAF1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      16273966..16406501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478230.2 → XP_021333905.1  FAS-associated factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QIJ3
      Conserved Domains (4) summary
      cd01769
      Location:133 → 195
      UBL; Ubiquitin-like domain of UBL
      cd01771
      Location:594 → 673
      Faf1_UBX; Faf1 UBX domain
      cd02990
      Location:376 → 511
      UAS_FAF1; UAS family, FAS-associated factor 1 (FAF1) subfamily; FAF1 contains a UAS domain of unknown function N-terminal to a ubiquitin-associated UBX domain. FAF1 also contains ubiquitin-associated UBA and nuclear targeting domains, N-terminal to the UAS domain. ...
      cd14413
      Location:16 → 48
      UBA_FAF1; UBA-like domain found in FAS-associated factor 1 (FAF1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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