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    grk5 G protein-coupled receptor kinase 5 [ Danio rerio (zebrafish) ]

    Gene ID: 560806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    grk5provided by ZNC
    Official Full Name
    G protein-coupled receptor kinase 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091204-274
    See related
    Ensembl:ENSDARG00000032801 AllianceGenome:ZFIN:ZDB-GENE-091204-274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-171l20.1
    Summary
    Predicted to enable protein kinase activity. Acts upstream of or within heart development; positive regulation of Wnt signaling pathway; and regulation of heart contraction. Predicted to be active in cytoplasm. Is expressed in brain; cardiovascular system; and otic vesicle. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See grk5 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (2715391..2755381)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (2688377..2728207)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene SET domain containing 9 Neighboring gene mesoderm induction early response 1, family member 3 a Neighboring gene ash2 like, histone lysine methyltransferase complex subunit Neighboring gene posterior neuron-specific homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development. Philipp M, et al. J Biol Chem, 2014 Sep 19. PMID 25104355, Free PMC Article
    2. G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. Chen M, et al. J Biol Chem, 2009 Dec 11. PMID 19801552, Free PMC Article
    3. An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Zhao Z, et al. EMBO Rep, 2016 May. PMID 27113758, Free PMC Article
    4. Grk5l controls heart development by limiting mTOR signaling during symmetry breaking. Burkhalter MD, et al. Cell Rep, 2013 Aug 29. PMID 23972986, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRK2 and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes.
      Title: Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development.
    2. Grk5l influences development of the heart during its early formation.
      Title: Grk5l controls heart development by limiting mTOR signaling during symmetry breaking.
    3. Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling.
      Title: G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G protein-coupled receptor kinase 5
    NP_001166974.1
    XP_021334860.1
    XP_068079905.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173503.1 → NP_001166974.1  G protein-coupled receptor kinase 5

      Status: VALIDATED

      Source sequence(s)
      BC155606, BQ419577, EH480419
      UniProtKB/TrEMBL
      A0A8M1NUN2, F1RAR9
      Related
      ENSDARP00000104968.2, ENSDART00000130793.4
      Conserved Domains (3) summary
      smart00220
      Location:180 → 443
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:35 → 173
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:180 → 464
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      2715391..2755381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223804.1 → XP_068079905.1  G protein-coupled receptor kinase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M1NUN2, F1RAR9

    2. XM_021479185.2 → XP_021334860.1  G protein-coupled receptor kinase 5 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QKR0, A9JRC5
      Conserved Domains (2) summary
      cl02565
      Location:35 → 173
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:180 → 464
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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