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    zp2l2 zona pellucida glycoprotein 2, like 2 [ Danio rerio (zebrafish) ]

    Gene ID: 559251, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zp2l2provided by ZNC
    Official Full Name
    zona pellucida glycoprotein 2, like 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060818-4
    See related
    Ensembl:ENSDARG00000004898 AllianceGenome:ZFIN:ZDB-GENE-060818-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zp2v2; zpb2c; zgc:162961
    Summary
    Predicted to enable acrosin binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Predicted to act upstream of or within single fertilization. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and egg coat. Orthologous to human ZP4 (zona pellucida glycoprotein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See zp2l2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (9945317..9952103, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (9709778..9716564, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 237b Neighboring gene serine/threonine-protein kinase pim-1-like Neighboring gene cytochrome P450, family 20, subfamily A, polypeptide 1 Neighboring gene abl-interactor 2b Neighboring gene integral membrane protein 2Ba

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Tandem-repeated Zebrafish zp3 genes possess oocyte-specific promoters and are insensitive to estrogen induction. Liu X, et al. Biol Reprod, 2006 Jun. PMID 16481590
    2. Bioinformatic analyses of zona pellucida genes in vertebrates and their expression in Nile tilapia. Wu T, et al. Fish Physiol Biochem, 2018 Apr. PMID 29307115
    3. The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Shankar P, et al. Toxicol Sci, 2022 May 26. PMID 35377459, Free PMC Article
    4. Early depletion of primordial germ cells in zebrafish promotes testis formation. Tzung KW, et al. Stem Cell Reports, 2015 Jan 13. PMID 25434820, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC162961

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acrosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of egg coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prevention of polyspermy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in egg coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zona pellucida glycoprotein 2, like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089502.1 → NP_001082971.1  zona pellucida glycoprotein 2, like 2 precursor

      See identical proteins and their annotated locations for NP_001082971.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134168
      UniProtKB/TrEMBL
      A3KP56
      Related
      ENSDARP00000065474.5, ENSDART00000065475.6
      Conserved Domains (3) summary
      smart00018
      Location:67 → 107
      PD; P or trefoil or TFF domain
      smart00241
      Location:110 → 390
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:262 → 389
      Zona_pellucida; Zona pellucida-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      9945317..9952103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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