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    kdm7aa lysine (K)-specific demethylase 7Aa [ Danio rerio (zebrafish) ]

    Gene ID: 321248, updated on 27-Dec-2024

    Summary

    Official Symbol
    kdm7aaprovided by ZNC
    Official Full Name
    lysine (K)-specific demethylase 7Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9829
    See related
    Ensembl:ENSDARG00000018111 AllianceGenome:ZFIN:ZDB-GENE-030131-9829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb414; kdm7a; jhdm1da; sb:cb414; zgc:123306; DKEY-105O6.2; si:dkey-105o6.2
    Summary
    Enables histone H3K27me2/H3K27me3 demethylase activity and histone H3K9 demethylase activity. Involved in midbrain development. Predicted to be located in nucleus. Is expressed in several structures, including anterior axial hypoblast; immature eye; margin; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human KDM7A (lysine demethylase 7A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See kdm7aa in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (22482661..22519525, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (22763855..22798550, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene LHFPL tetraspan subfamily member 3 Neighboring gene lysine (K)-specific methyltransferase 2E Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C Neighboring gene CD36 molecule (CD36 blood group)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Clone Names

    • MGC123306

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity  
    enables 2-oxoglutarate-dependent dioxygenase activity  
    enables dioxygenase activity  
    enables histone H3K27me2/H3K27me3 demethylase activity PubMed 
    enables histone H3K27me2/H3K27me3 demethylase activity  
    enables histone H3K36 demethylase activity  
    enables histone H3K9 demethylase activity PubMed 
    enables histone H3K9 demethylase activity  
    enables histone H4K20 demethylase activity  
    enables histone demethylase activity  
    enables metal ion binding  
    enables oxidoreductase activity  
    enables transcription coregulator activity  
    Component Evidence Code Pubs
    located_in nucleus  

    General protein information

    Preferred Names
    lysine-specific demethylase 7A
    Names
    jmjC domain-containing histone demethylation protein 1D-A
    jumonji C domain containing histone demethylase 1 homolog D
    jumonji C domain containing histone demethylase 1 homolog Da
    NP_001333080.1
    XP_068075614.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346151.1 → NP_001333080.1  lysine-specific demethylase 7A

      Status: VALIDATED

      Source sequence(s)
      BX537168
      UniProtKB/Swiss-Prot
      A5PL83, Q5RHD1
      UniProtKB/TrEMBL
      A0A2R8RKB3, A0A8M1PAD2
      Related
      ENSDARP00000147148.1, ENSDART00000186258.1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      22482661..22519525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219513.1 → XP_068075614.1  lysine-specific demethylase 7A isoform X1

      UniProtKB/Swiss-Prot
      A5PL83, Q5RHD1
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