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    cry-dash cryptochrome DASH [ Danio rerio (zebrafish) ]

    Gene ID: 402986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cry-dashprovided by ZNC
    Official Full Name
    cryptochrome DASHprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040617-2
    See related
    Ensembl:ENSDARG00000002396 AllianceGenome:ZFIN:ZDB-GENE-040617-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zcry-dash
    Summary
    Enables damaged DNA binding activity; deoxyribodipyrimidine photo-lyase activity; and flavin adenine dinucleotide binding activity. Acts upstream of or within photoreactive repair. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cry-dash in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (20194021..20208347, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (20049602..20063928, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene antifreeze protein Maxi-like Neighboring gene MYD88 innate immune signal transduction adaptor Neighboring gene uncharacterized LOC100334155 Neighboring gene mitogen-activated protein kinase kinase kinase 22 Neighboring gene acetyl-CoA acyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Involvement of electron transfer in the photoreaction of zebrafish Cryptochrome-DASH. Zikihara K, et al. Photochem Photobiol, 2008 Jul-Aug. PMID 18494763
    2. Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness. Zhao H, et al. Curr Biol, 2018 Oct 22. PMID 30318355
    3. Acute exposure to ustiloxin A affects growth and development of early life zebrafish, Danio rerio. Hu Z, et al. Chemosphere, 2019 Jul. PMID 30978596
    4. The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish. Hirayama J, et al. Sci Rep, 2019 Jan 17. PMID 30655599, Free PMC Article
    5. Transcriptomic characterization of cold acclimation in larval zebrafish. Long Y, et al. BMC Genomics, 2013 Sep 11. PMID 24024969, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. First report on the photoreaction pathway and kinetics of a vertebrate (zebrafish) Cry-DASH family protein.
      Title: Involvement of electron transfer in the photoreaction of zebrafish Cryptochrome-DASH.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC109715

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA photolyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deoxyribodipyrimidine photo-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribodipyrimidine photo-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in photoreactive repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within photoreactive repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cryptochrome DASH
    Names
    dash photolyase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205686.1 → NP_991249.1  cryptochrome DASH

      See identical proteins and their annotated locations for NP_991249.1

      Status: PROVISIONAL

      Source sequence(s)
      AB120759
      UniProtKB/Swiss-Prot
      Q4KML2, Q75WS5
      Related
      ENSDARP00000121988.1, ENSDART00000139329.2
      Conserved Domains (3) summary
      TIGR02765
      Location:5 → 438
      crypto_DASH; cryptochrome, DASH family
      pfam00875
      Location:7 → 174
      DNA_photolyase; DNA photolyase
      pfam03441
      Location:218 → 473
      FAD_binding_7; FAD binding domain of DNA photolyase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      20194021..20208347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KML2.2 GenPept UniProtKB/Swiss-Prot:Q4KML2

    Gene LinkOut

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