rgma repulsive guidance molecule BMP co-receptor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rgmaprovided by ZNC
Official Full Name: repulsive guidance molecule BMP co-receptor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040527-1
See related: Ensembl:ENSDARG00000012248 AllianceGenome:ZFIN:ZDB-GENE-040527-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dlm; hfe2; rgmc; id:ibd2030; wu:fb72h09; zgc:110534
Summary: Predicted to enable coreceptor activity. Acts upstream of with a positive effect on membrane protein intracellular domain proteolysis. Acts upstream of or within cell morphogenesis. Predicted to be located in side of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; hindbrain neural plate; hindbrain neural rod; notochord; and tail bud. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human RGMA (repulsive guidance molecule BMP co-receptor a). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (24919614..24932060)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (24933082..24945528)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We reveal that Rgma-Neo1 signaling controls neuroepithelial cel elongation independently of the establishment of apical junctional complexes and identify Rgma-induced Neo1 proteolytic cleavage as a key upstream signaling event
Title: Rgma-Induced Neo1 Proteolysis Promotes Neural Tube Morphogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect membrane protein intracellular domain proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: repulsive guidance molecule A

Names: RGM domain family, member A; dragon-like muscle; repulsive guidance molecule c; repulsive guidance molecule family member a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045011.1 → NP_001038476.1 repulsive guidance molecule A

Status: PROVISIONAL

Source sequence(s)

BX649578

UniProtKB/TrEMBL

A0A8M1NA01, Q1LVM8

Related

ENSDARP00000027966.8, ENSDART00000008638.9

Conserved Domains (2) summary

pfam06534
Location:227 → 408

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:48 → 221

RGM_N; Repulsive guidance molecule (RGM) N-terminus