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    tnni2b.1 troponin I type 2b (skeletal, fast), tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 550249, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tnni2b.1provided by ZNC
    Official Full Name
    troponin I type 2b (skeletal, fast), tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-49
    See related
    Ensembl:ENSDARG00000035958 AllianceGenome:ZFIN:ZDB-GENE-050417-49
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tropI-2a; zgc:110715
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in cardiac muscle contraction and skeletal muscle contraction. Predicted to be part of troponin complex. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TNNI2 (troponin I2, fast skeletal type). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tnni2b.1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (39401388..39406765)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (39130371..39135748)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member B1 Neighboring gene troponin I type 2b (skeletal, fast), tandem duplicate 2 Neighboring gene lymphocyte specific protein 1 b Neighboring gene mucin-17 Neighboring gene troponin T type 3b (skeletal, fast)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivo. Hofeichner J, et al. Sci Rep, 2023 Dec 19. PMID 38114601, Free PMC Article
    2. Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC. Genge CE, et al. Genome Biol Evol, 2016 Apr 11. PMID 26979795, Free PMC Article
    3. Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos. Hausen J, et al. Environ Sci Pollut Res Int, 2018 Feb. PMID 28391457
    4. A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Seda M, et al. Sci Rep, 2023 Apr 26. PMID 37100808, Free PMC Article
    5. "Young at heart": Regenerative potential linked to immature cardiac phenotypes. Gomes RS, et al. J Mol Cell Cardiol, 2016 Mar. PMID 26827899, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    troponin I type 2b (skeletal, fast), tandem duplicate 1
    Names
    troponin I, skeletal, fast 2b.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017587.2 → NP_001017587.2  troponin I type 2b (skeletal, fast), tandem duplicate 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT030188, EH474473
      UniProtKB/TrEMBL
      A0A8M1NJH6, F1QCC0, Q567W1
      Related
      ENSDARP00000023228.9, ENSDART00000025852.10
      Conserved Domains (1) summary
      pfam00992
      Location:11 → 137
      Troponin; Troponin

    2. NM_001136492.2 → NP_001129964.1  troponin I type 2b (skeletal, fast), tandem duplicate 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT030188, CT600646, EH477096
      UniProtKB/TrEMBL
      A0A8M1NJH6, F1QCC0, Q567W1
      Related
      ENSDARP00000120317.1, ENSDART00000144750.3
      Conserved Domains (1) summary
      pfam00992
      Location:11 → 137
      Troponin; Troponin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      39401388..39406765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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