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    spag6 sperm associated antigen 6 [ Danio rerio (zebrafish) ]

    Gene ID: 431757, updated on 4-Jan-2025

    Summary

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    Official Symbol
    spag6provided by ZNC
    Official Full Name
    sperm associated antigen 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040704-53
    See related
    Ensembl:ENSDARG00000020158 AllianceGenome:ZFIN:ZDB-GENE-040704-53
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:91805
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in epithelial cilium movement involved in extracellular fluid movement and plasma membrane bounded cell projection organization. Predicted to be active in acrosomal vesicle; cytoskeleton; and sperm principal piece. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; nervous system; pronephric duct; and spinal cord neural tube. Orthologous to human SPAG6 (sperm associated antigen 6). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See spag6 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (17269872..17276771)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (17125453..17132352)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene COMM domain containing 3 Neighboring gene bmi1 polycomb ring finger oncogene 1a Neighboring gene polycystin 1 like 1, transient receptor potential channel interacting Neighboring gene si:dkey-117j14.6 Neighboring gene protein disulfide isomerase family A, member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionarily ancient association of the FoxJ1 transcription factor with the motile ciliogenic program. Vij S, et al. PLoS Genet, 2012. PMID 23144623, Free PMC Article
    2. Ccdc103 promotes myeloid cell proliferation and migration independent of motile cilia. Falkenberg LG, et al. Dis Model Mech, 2021 May 1. PMID 34028558, Free PMC Article
    3. Single-Cell RNA Sequencing Reveals Size-Dependent Effects of Polystyrene Microplastics on Immune and Secretory Cell Populations from Zebrafish Intestines. Gu W, et al. Environ Sci Technol, 2020 Mar 17. PMID 32092251
    4. Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. Austin-Tse C, et al. Am J Hum Genet, 2013 Oct 3. PMID 24094744, Free PMC Article
    5. Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes. England SJ, et al. Front Cell Dev Biol, 2017. PMID 28271061, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cilium movement involved in extracellular fluid movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sperm-associated antigen 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002210.1 → NP_001002210.1  sperm-associated antigen 6

      See identical proteins and their annotated locations for NP_001002210.1

      Status: PROVISIONAL

      Source sequence(s)
      BC074072
      UniProtKB/TrEMBL
      B2GRM8, Q6GMH8
      Related
      ENSDARP00000023131.7, ENSDART00000017605.8
      Conserved Domains (3) summary
      cd00020
      Location:77 → 195
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00044
      Location:293 → 316
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:120 → 152
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      17269872..17276771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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