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    ssh2b slingshot protein phosphatase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 557912, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ssh2bprovided by ZNC
    Official Full Name
    slingshot protein phosphatase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081205-4
    See related
    Ensembl:ENSDARG00000098955 AllianceGenome:ZFIN:ZDB-GENE-081205-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:175142
    Summary
    Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in actin cytoskeleton organization and negative regulation of actin filament polymerization. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human SSH2 (slingshot protein phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ssh2b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (40417152..40478294)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (40393599..40454734)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100534731 Neighboring gene small nucleolar RNA SNORD65 Neighboring gene nuclear speckle splicing regulatory protein 1 Neighboring gene coronin 6 Neighboring gene protein ABHD15 Neighboring gene TAO kinase 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of the tbx6/16 subfamily genes in vertebrates: insights from zebrafish. Ahn D, et al. Mol Biol Evol, 2012 Dec. PMID 22915831
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC175142

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase Slingshot homolog 2b
    Names
    slingshot homolog 2b
    NP_001128575.1
    XP_009293925.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135103.1 → NP_001128575.1  protein phosphatase Slingshot homolog 2b

      See identical proteins and their annotated locations for NP_001128575.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168509
      UniProtKB/TrEMBL
      B5DE33
      Related
      ENSDARP00000131244.1, ENSDART00000171244.2
      Conserved Domains (3) summary
      cd11652
      Location:3 → 240
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:312 → 447
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:258 → 306
      DEK_C; DEK C terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      40417152..40478294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009295650.4 → XP_009293925.1  protein phosphatase Slingshot homolog 2b isoform X1

      UniProtKB/TrEMBL
      A0A2R8RXU6, A0A8M3AX49
      Related
      ENSDARP00000155575.1, ENSDART00000190675.1
      Conserved Domains (3) summary
      cd11652
      Location:38 → 254
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:326 → 461
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:272 → 320
      DEK_C; DEK C terminal domain
    Nucleotide Protein
    Heading Accession and Version

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