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    pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta [ Danio rerio (zebrafish) ]

    Gene ID: 567938, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pik3c2bprovided by ZNC
    Official Full Name
    phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 betaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050309-145
    See related
    Ensembl:ENSDARG00000086927 AllianceGenome:ZFIN:ZDB-GENE-050309-145
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7150469
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Predicted to be involved in cell migration; intracellular signal transduction; and phosphatidylinositol-3-phosphate biosynthetic process. Predicted to act upstream of or within phosphatidylinositol phosphate biosynthetic process and phosphorylation. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including margin; mesoderm; nervous system; neural plate; and notochord. Orthologous to human PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pik3c2b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (23595387..23696729, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (23354121..23458896, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882447 Neighboring gene protein phosphatase 1, regulatory subunit 15B Neighboring gene uncharacterized LOC137490423 Neighboring gene uncharacterized LOC137490424 Neighboring gene neurofascin homolog (chicken) a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models. Sabha N, et al. J Clin Invest, 2016 Sep 1. PMID 27548528, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pik3c2b is a genetic modifier of Mtm1 mutation with a role in function and survival in myotubular myopathy animal models
      Title: PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
    Names
    phosphoinositide-3-kinase, class 2, beta polypeptide
    XP_003199535.1
    XP_009304289.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      23595387..23696729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003199487.6 → XP_003199535.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

      See identical proteins and their annotated locations for XP_003199535.1

      UniProtKB/TrEMBL
      A0A8M1RIX8, F1QWN6
      Related
      ENSDARP00000110942.2, ENSDART00000124810.4
      Conserved Domains (6) summary
      cd00895
      Location:934 → 1287
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd04012
      Location:569 → 741
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1458 → 1579
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cl00271
      Location:763 → 928
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
      cl02484
      Location:322 → 413
      PI3K_rbd; PI3-kinase family, ras-binding domain
      cl02563
      Location:1317 → 1425
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. XM_009306014.4 → XP_009304289.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

      See identical proteins and their annotated locations for XP_009304289.1

      UniProtKB/TrEMBL
      A0A8M1RIX8, F1QWN6
      Related
      ENSDARP00000154070.1, ENSDART00000189599.1
      Conserved Domains (6) summary
      cd00895
      Location:934 → 1287
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd04012
      Location:569 → 741
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1458 → 1579
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cl00271
      Location:763 → 928
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
      cl02484
      Location:322 → 413
      PI3K_rbd; PI3-kinase family, ras-binding domain
      cl02563
      Location:1317 → 1425
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein Strain
    Heading Accession and Version

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