rab11bb RAB11B, member RAS oncogene family, b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rab11bbprovided by ZNC
Official Full Name: RAB11B, member RAS oncogene family, bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-293
See related: Ensembl:ENSDARG00000090086 AllianceGenome:ZFIN:ZDB-GENE-040718-293
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92772
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in constitutive secretory pathway and regulated exocytosis. Predicted to be active in Golgi apparatus and recycling endosome. Is expressed in cardiovascular system; nervous system; pharyngeal arch; pronephric duct; and spinal cord neural tube. Orthologous to human RAB11B (RAB11B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (56463167..56476990)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (56339322..56353145)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab11 promotes single Mauthner cell axon regeneration in vivo through axon guidance molecule Ntng2b.
Title: Rab11 promotes single Mauthner cell axon regeneration in vivo through axon guidance molecule Ntng2b.
Results found all three rab11 genes (rab11a, rab11ba and rab11bb) are highly conserved especially for their GTPase domains, and highly enriched in the central nervous system, but in different areas of the brain. rab11bb was also expressed in kidney, fin and spinal cord. During embryogenesis, rab11bb only expresses during 24hpf to 96hpf.
Title: Expression analysis of Rab11 during zebrafish embryonic development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in constitutive secretory pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RAB11B, member RAS oncogene family, b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002555.1 → NP_001002555.1 RAB11B, member RAS oncogene family, b

See identical proteins and their annotated locations for NP_001002555.1

Status: PROVISIONAL

Source sequence(s)

BC076247

UniProtKB/TrEMBL

A0A8M1N0N4, Q6DGU2

Related

ENSDARP00000111631.1, ENSDART00000123392.3

Conserved Domains (2) summary

PLN03110
Location:1 → 217

PLN03110; Rab GTPase; Provisional

cd01868
Location:9 → 173

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25