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    cert1a ceramide transporter 1a [ Danio rerio (zebrafish) ]

    Gene ID: 796455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cert1aprovided by ZNC
    Official Full Name
    ceramide transporter 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080724-10
    See related
    Ensembl:ENSDARG00000024325 AllianceGenome:ZFIN:ZDB-GENE-080724-10
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cert1; col4a3bp; col4a3bpa; zgc:92147; wu:fc37f11
    Summary
    Predicted to enable ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Predicted to be involved in ER to Golgi ceramide transport and intermembrane lipid transfer. Predicted to act upstream of or within lipid transport and muscle organ development. Predicted to be located in Golgi apparatus. Predicted to be active in cytosol. Is expressed in immature eye. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 34. Orthologous to human CERT1 (ceramide transporter 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cert1a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (50913300..50967971)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (50266707..50321378)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene nucleolar protein 6 (RNA-associated) Neighboring gene arylsulfatase family, member K Neighboring gene 3-hydroxy-3-methylglutaryl-CoA reductase a Neighboring gene uncharacterized LOC137495632

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development. Granero-Moltó F, et al. J Biol Chem, 2008 Jul 18. PMID 18424781, Free PMC Article
    2. Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair. Simões FC, et al. Nat Commun, 2020 Jan 30. PMID 32001677, Free PMC Article
    3. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
    4. Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. Casey MA, et al. G3 (Bethesda), 2022 Mar 4. PMID 35079792, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study found both GPBP isoforms are expressed during early development &, when depleted, lead to apoptosis; results suggest GPBP is an important factor for normal skeletal muscle & brain development
      Title: Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ceramide 1-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide 1-phosphate transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ceramide transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ER to Golgi ceramide transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ceramide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intermembrane lipid transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ceramide transfer protein
    Names
    WITHDRAWN:zgc:92147
    cert
    collagen type IV alpha-3-binding protein
    collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
    goodpasture antigen-binding protein
    NP_001017914.3
    NP_001268801.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017914.4 → NP_001017914.3  ceramide transfer protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      BX000437
      UniProtKB/Swiss-Prot
      A2BGX3, A2BGX4, B4XAM8, B4XAM9, Q5M7Y0
      UniProtKB/TrEMBL
      A0A8M1N5P3, F8W2V5
      Related
      ENSDARP00000124594.1, ENSDART00000149787.3
      Conserved Domains (2) summary
      cd08872
      Location:387 → 620
      START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
      cd13283
      Location:23 → 122
      PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain

    2. NM_001281872.1 → NP_001268801.1  ceramide transfer protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BX000437
      UniProtKB/Swiss-Prot
      A2BGX3, A2BGX4, B4XAM8, B4XAM9, Q5M7Y0
      UniProtKB/TrEMBL
      A0A2R9YJF5, A0A8M1P0R7
      Related
      ENSDARP00000153901.1, ENSDART00000190837.1
      Conserved Domains (2) summary
      cd08872
      Location:360 → 594
      START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
      cd13283
      Location:23 → 122
      PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      50913300..50967971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394610.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      43526..97594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001100960.1: Suppressed sequence

      Description
      NM_001100960.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M7Y0.2 GenPept UniProtKB/Swiss-Prot:Q5M7Y0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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