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    fsd1 fibronectin type III and SPRY domain containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 566722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fsd1provided by ZNC
    Official Full Name
    fibronectin type III and SPRY domain containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-218
    See related
    Ensembl:ENSDARG00000062017 AllianceGenome:ZFIN:ZDB-GENE-060503-218
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-232d19.3
    Summary
    Predicted to enable microtubule binding activity. Acts upstream of or within with a positive effect on cilium assembly. Predicted to be located in several cellular components, including centrosome; cleavage furrow; and nucleus. Predicted to be active in microtubule. Orthologous to human FSD1 (fibronectin type III and SPRY domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fsd1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (18624658..18647347)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (18593664..18617147)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene coproporphyrinogen oxidase Neighboring gene coiled-coil domain containing 181 Neighboring gene signal transducing adaptor family member 2b Neighboring gene serine/threonine-protein kinase pim-2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis. Tu HQ, et al. Nat Commun, 2018 Dec 11. PMID 30538248, Free PMC Article
    2. Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Liu Z, et al. Nat Commun, 2019 Apr 23. PMID 31015398, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin type III and SPRY domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045117.3 → NP_001038582.1  fibronectin type III and SPRY domain-containing protein 1

      See identical proteins and their annotated locations for NP_001038582.1

      Status: VALIDATED

      Source sequence(s)
      BC162320, BX247907
      UniProtKB/Swiss-Prot
      Q1LY10
      UniProtKB/TrEMBL
      B3DG96
      Related
      ENSDARP00000083574.5, ENSDART00000089141.5
      Conserved Domains (3) summary
      cd00063
      Location:165 → 265
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12901
      Location:270 → 475
      SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
      cl23765
      Location:4 → 127
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      18624658..18647347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1LY10.1 GenPept UniProtKB/Swiss-Prot:Q1LY10

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