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    ndufaf5 NADH:ubiquinone oxidoreductase complex assembly factor 5 [ Danio rerio (zebrafish) ]

    Gene ID: 794020, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndufaf5provided by ZNC
    Official Full Name
    NADH:ubiquinone oxidoreductase complex assembly factor 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-110
    See related
    Ensembl:ENSDARG00000061629 AllianceGenome:ZFIN:ZDB-GENE-070410-110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:162919
    Summary
    Predicted to enable S-adenosylmethionine-dependent methyltransferase activity and oxidoreductase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly and peptidyl-arginine hydroxylation. Predicted to act upstream of or within methylation. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 16. Orthologous to human NDUFAF5 (NADH:ubiquinone oxidoreductase complex assembly factor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ndufaf5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (51221300..51231402)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (50577539..50585657)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene BTB (POZ) domain containing 3a Neighboring gene ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) Neighboring gene kinesin family member 16Ba Neighboring gene microtubule associated serine/threonine kinase 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC162919

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-arginine hydroxylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arginine-hydroxylase NDUFAF5, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5
    probable methyltransferase C20orf7 homolog, mitochondrial
    putative methyltransferase NDUFAF5
    NP_001076363.2
    XP_068076960.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082894.2 → NP_001076363.2  arginine-hydroxylase NDUFAF5, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      CU138540
      UniProtKB/Swiss-Prot
      A3KP37
      Related
      ENSDARP00000113500.2, ENSDART00000138878.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      51221300..51231402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068220859.1 → XP_068076960.1  arginine-hydroxylase NDUFAF5, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      A3KP37
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3KP37.1 GenPept UniProtKB/Swiss-Prot:A3KP37

    Gene LinkOut

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