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    mboat7 membrane bound O-acyltransferase domain containing 7 [ Danio rerio (zebrafish) ]

    Gene ID: 393509, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mboat7provided by ZNC
    Official Full Name
    membrane bound O-acyltransferase domain containing 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1516
    See related
    Ensembl:ENSDARG00000033436 AllianceGenome:ZFIN:ZDB-GENE-040426-1516
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    leng4; zgc:66032
    Summary
    Predicted to enable O-acyltransferase activity and lysophospholipid acyltransferase activity. Predicted to be involved in glycerophospholipid metabolic process; lipid modification; and regulation of triglyceride metabolic process. Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane and mitochondria-associated endoplasmic reticulum membrane contact site. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 57. Orthologous to human MBOAT7 (membrane bound O-acyltransferase domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mboat7 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (32014567..32026764)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (32060586..32072418)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene serine/threonine/tyrosine kinase 1b Neighboring gene glutathione S-transferase kappa 1 Neighboring gene glutathione S-transferase kappa 4 Neighboring gene transmembrane channel-like 4 Neighboring gene leukocyte receptor cluster (LRC) member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish. Kossack ME, et al. Genetics, 2019 Jan. PMID 30446521, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66032

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylcholine acyl-chain remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylinositol acyl-chain remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of triglyceride metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysophospholipid acyltransferase 7
    Names
    LPLAT 7
    O-acyltransferase domain-containing protein 7
    leukocyte receptor cluster (LRC) member 4
    leukocyte receptor cluster member 4
    membrane-bound O-acyltransferase domain-containing protein 7
    NP_956831.1
    XP_021322322.1
    XP_068070018.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200537.1 → NP_956831.1  lysophospholipid acyltransferase 7

      See identical proteins and their annotated locations for NP_956831.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056305
      UniProtKB/Swiss-Prot
      Q7SZQ0
      Related
      ENSDARP00000047569.5, ENSDART00000047570.6
      Conserved Domains (1) summary
      cl00738
      Location:2 → 455
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      32014567..32026764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466647.2 → XP_021322322.1  lysophospholipid acyltransferase 7 isoform X2

      UniProtKB/TrEMBL
      A0A8M9NZ64, F1Q9V3
      Conserved Domains (1) summary
      cl00738
      Location:2 → 455
      MBOAT; membrane-bound O-acyltransferase family

    2. XM_068213917.1 → XP_068070018.1  lysophospholipid acyltransferase 7 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SZQ0.1 GenPept UniProtKB/Swiss-Prot:Q7SZQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.