uck2a uridine-cytidine kinase 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uck2aprovided by ZNC
Official Full Name: uridine-cytidine kinase 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7158
See related: Ensembl:ENSDARG00000006074 AllianceGenome:ZFIN:ZDB-GENE-030131-7158
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: umpk; zgc:66240; wu:fk91a01
Summary: Predicted to enable cytidine kinase activity and uridine kinase activity. Predicted to be involved in CTP salvage and UMP salvage. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Orthologous to human UCK2 (uridine-cytidine kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (21114338..21133119)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (21082253..21101034)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi54d06.y1 (e-PCR)
- UniSTS:197701

fk91a01.x1 (e-PCR)
- UniSTS:201703

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytidine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables uridine kinase activity	IEA Inferred from Electronic Annotation more info
enables uridine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in CTP salvage	IEA Inferred from Electronic Annotation more info
involved_in CTP salvage	ISS Inferred from Sequence or Structural Similarity more info
involved_in UMP salvage	IEA Inferred from Electronic Annotation more info
involved_in UMP salvage	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uridine-cytidine kinase 2-A

Names: UCK 2-A; cytidine monophosphokinase 2-A; uridine monophosphate kinase; uridine monophosphokinase 2-A

NP_001164538.1

EC 2.7.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171067.1 → NP_001164538.1 uridine-cytidine kinase 2-A

See identical proteins and their annotated locations for NP_001164538.1

Status: PROVISIONAL

Source sequence(s)

BX927144

UniProtKB/Swiss-Prot

Q7SYM0

Related

ENSDARP00000018636.7, ENSDART00000002186.8

Conserved Domains (2) summary

COG0572
Location:21 → 232

Udk; Uridine kinase [Nucleotide transport and metabolism]

cd02023
Location:24 → 229

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...