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    eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta [ Danio rerio (zebrafish) ]

    Gene ID: 541548, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif2b4provided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 2B, subunit 4 deltaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-955
    See related
    Ensembl:ENSDARG00000014004 AllianceGenome:ZFIN:ZDB-GENE-030131-955
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb54a09; zgc:110790; si:ch211-101l18.4
    Summary
    Predicted to enable translation initiation factor activity. Predicted to act upstream of or within translational initiation. Predicted to be located in cytosol. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See eif2b4 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (19516651..19532536, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (19617071..19633023, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene sorting nexin 17 Neighboring gene all-trans retinoic acid-induced differentiation factor Neighboring gene uncharacterized LOC137488637 Neighboring gene transfer RNA leucine (anticodon CAG) Neighboring gene microRNA 133b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response. Keefe MD, et al. Elife, 2020 Dec 10. PMID 33300869, Free PMC Article
    2. Evolution and genomic organization of muscle microRNAs in fish genomes. Nachtigall PG, et al. BMC Evol Biol, 2014 Sep 25. PMID 25253178, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    translation initiation factor eIF2B subunit delta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014361.2 → NP_001014383.1  translation initiation factor eIF2B subunit delta

      See identical proteins and their annotated locations for NP_001014383.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091878
      UniProtKB/TrEMBL
      Q58EJ2, Q5RIE1
      Related
      ENSDARP00000106707.2, ENSDART00000125830.4
      Conserved Domains (3) summary
      PHA01732
      Location:74 → 137
      PHA01732; proline-rich protein
      COG1184
      Location:220 → 534
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:236 → 526
      IF-2B; Initiation factor 2 subunit family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      19516651..19532536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160461.5 → XP_005160518.1  translation initiation factor eIF2B subunit delta isoform X2

      UniProtKB/TrEMBL
      A0A286Y8J6, A0A8M2B7A7
      Related
      ENSDARP00000143268.1, ENSDART00000179566.2
      Conserved Domains (3) summary
      PHA01732
      Location:74 → 137
      PHA01732; proline-rich protein
      COG1184
      Location:234 → 548
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:250 → 540
      IF-2B; Initiation factor 2 subunit family

    2. XM_005160462.5 → XP_005160519.1  translation initiation factor eIF2B subunit delta isoform X3

      UniProtKB/TrEMBL
      A0A8M2B7A3
      Conserved Domains (2) summary
      COG1184
      Location:221 → 535
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:237 → 527
      IF-2B; Initiation factor 2 subunit family

    3. XM_005160460.5 → XP_005160517.1  translation initiation factor eIF2B subunit delta isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7A1
      Conserved Domains (2) summary
      COG1184
      Location:235 → 549
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:251 → 541
      IF-2B; Initiation factor 2 subunit family
    Nucleotide Protein Strain
    Heading Accession and Version

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