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    nfia nuclear factor I/A [ Danio rerio (zebrafish) ]

    Gene ID: 556665, updated on 27-Dec-2024

    Summary

    Official Symbol
    nfiaprovided by ZNC
    Official Full Name
    nuclear factor I/Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050208-501
    See related
    Ensembl:ENSDARG00000062420 AllianceGenome:ZFIN:ZDB-GENE-050208-501
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fq27e07; zgc:158351; si:ch211-88d2.2
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within axon development. Predicted to be located in nucleus. Is expressed in brain. Human ortholog(s) of this gene implicated in NFIA-related disorder. Orthologous to human NFIA (nuclear factor I A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See nfia in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (16835752..17064739, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (16812860..17027331, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene PATJ crumbs cell polarity complex component Neighboring gene si:dkey-38n4.2 Neighboring gene TM2 domain containing 1 Neighboring gene uncharacterized LOC137488917 Neighboring gene microRNA mir-2194 Neighboring gene uncharacterized LOC137488918 Neighboring gene Fras1 related extracellular matrix 1b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription factor activity  
    Component Evidence Code Pubs
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079962.1NP_001073431.1  nuclear factor 1 A-type

      See identical proteins and their annotated locations for NP_001073431.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128847
      UniProtKB/TrEMBL
      A1A5X3
      Related
      ENSDARP00000084670.4, ENSDART00000090237.6
      Conserved Domains (3) summary
      cl00055
      Location:68172
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:213480
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:846
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      16835752..17064739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216301.1XP_068072402.1  nuclear factor 1 A-type isoform X9

    2. XM_009296239.4XP_009294514.1  nuclear factor 1 A-type isoform X3

      UniProtKB/TrEMBL
      A0A8M3AMZ3
      Conserved Domains (3) summary
      cl00055
      Location:91195
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:236566
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3269
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    3. XM_009296243.4XP_009294518.1  nuclear factor 1 A-type isoform X8

      UniProtKB/TrEMBL
      A0A8M3B5H7
      Conserved Domains (3) summary
      cl00055
      Location:91195
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:236526
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3269
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    4. XM_009296237.4XP_009294512.1  nuclear factor 1 A-type isoform X2

      UniProtKB/TrEMBL
      A0A8M3AM79
      Conserved Domains (3) summary
      cl00055
      Location:91195
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:236569
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3269
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    5. XM_009296242.4XP_009294517.1  nuclear factor 1 A-type isoform X7

      UniProtKB/TrEMBL
      A0A8M3AM86
      Conserved Domains (3) summary
      cl00055
      Location:91195
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:236543
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3269
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    6. XM_009296240.4XP_009294515.1  nuclear factor 1 A-type isoform X4

      UniProtKB/TrEMBL
      A0A8M3AXN2
      Conserved Domains (3) summary
      cl00055
      Location:91195
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:236566
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3269
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    7. XM_009296236.4XP_009294511.1  nuclear factor 1 A-type isoform X1

      UniProtKB/TrEMBL
      A0A8M3AUN3
      Conserved Domains (3) summary
      cl00055
      Location:91195
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:236586
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3269
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    8. XM_068216299.1XP_068072400.1  nuclear factor 1 A-type isoform X6

    9. XM_009296241.4XP_009294516.1  nuclear factor 1 A-type isoform X5

      UniProtKB/TrEMBL
      A0A8M3AUN8
      Conserved Domains (3) summary
      cl00055
      Location:68172
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:213563
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:846
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
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