pax9 paired box 9 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pax9provided by ZNC
Official Full Name: paired box 9provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-399
See related: Ensembl:ENSDARG00000053829 AllianceGenome:ZFIN:ZDB-GENE-980526-399
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables sequence-specific DNA binding activity. Acts upstream of or within defense response to Gram-positive bacterium; regulation of neutrophil differentiation; and roof of mouth development. Predicted to be located in nucleus. Is expressed in several structures, including axial blood vessel; digestive system; hematopoietic system; oral ectoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human PAX9 (paired box 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (38236469..38244117, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (38288879..38296596, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish.
Title: Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish.
The phenotypes caused by the knockdown of Pax1b in zebrafish could not be phenocopied by pax9 morphilino and could not be rescued by either Pax1a or Pax9 overexpression.
Title: Characterization of zebrafish Pax1b and Pax9 in fin bud development.
Functional investigation of a subset of these genes, fgf10a, tgfb2, pax9, and smad5 revealed their necessity in zebrafish palatogenesis.
Title: Examination of a palatogenic gene program in zebrafish.

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General gene information

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Markers

PAX9 (e-PCR)
- UniSTS:205406

pax9 (e-PCR), detects polymorphism
- UniSTS:238245

pax9 (e-PCR), detects polymorphism
- UniSTS:205538

fj26a02.y1 (e-PCR)
- UniSTS:198900

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: paired box protein Pax-9

Names: etID309776.17; paired box gene 9; paired box homeotic gene 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.