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    ak1 adenylate kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 445486, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ak1provided by ZNC
    Official Full Name
    adenylate kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040822-37
    See related
    Ensembl:ENSDARG00000001950 AllianceGenome:ZFIN:ZDB-GENE-040822-37
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:91930
    Summary
    Predicted to enable adenylate kinase activity. Predicted to be involved in ADP biosynthetic process; AMP metabolic process; and ATP metabolic process. Predicted to act upstream of or within nucleoside triphosphate biosynthetic process and phosphorylation. Predicted to be active in cytosol. Is expressed in cephalic musculature; hypaxial myotome region; myotome; pectoral fin musculature; and somite. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ak1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (71699876..71722114, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (70926040..70948370, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein/retinoic acid inducible neural-specific 1 Neighboring gene uncharacterized LOC101883034 Neighboring gene endoglin Neighboring gene G protein signaling modulator 1b Neighboring gene LIM homeobox 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structural analyses of adenylate kinases from Antarctic and tropical fishes for understanding cold adaptation of enzymes. Moon S, et al. Sci Rep, 2017 Nov 22. PMID 29167503, Free PMC Article
    2. Molecular docking investigation of the amantadine binding to the enzymes upregulated or downregulated in Parkinson's disease. Ionescu MI. ADMET DMPK, 2020. PMID 35300368, Free PMC Article
    3. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Sugden WW, et al. Nat Cell Biol, 2017 Jun. PMID 28530658, Free PMC Article
    4. Hepatotoxicity assessment of Rhizoma Paridis in adult zebrafish through proteomes and metabolome. Jia Z, et al. Biomed Pharmacother, 2020 Jan. PMID 31766101
    5. α3Na+/K+-ATPase deficiency causes brain ventricle dilation and abrupt embryonic motility in zebrafish. Doğanli C, et al. J Biol Chem, 2013 Mar 29. PMID 23400780, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleobase-containing compound kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in AMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleoside triphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenylate kinase isoenzyme 1
    NP_001003993.1
    XP_005168740.1
    XP_009300331.1
    XP_017211559.1
    XP_068077250.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003993.1 → NP_001003993.1  adenylate kinase isoenzyme 1

      See identical proteins and their annotated locations for NP_001003993.1

      Status: PROVISIONAL

      Source sequence(s)
      BC080261
      UniProtKB/TrEMBL
      A0A8M2BGJ7, B2GNJ2, F6PFH0, Q68EH2
      Conserved Domains (2) summary
      TIGR01360
      Location:6 → 193
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:10 → 182
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      71699876..71722114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221149.1 → XP_068077250.1  adenylate kinase isoenzyme 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BGJ7, B2GNJ2, F6PFH0, Q68EH2

    2. XM_017356070.3 → XP_017211559.1  adenylate kinase isoenzyme 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BGJ7, B2GNJ2, F6PFH0, Q68EH2
      Related
      ENSDARP00000013777.6, ENSDART00000013404.8
      Conserved Domains (2) summary
      TIGR01360
      Location:6 → 193
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:10 → 182
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    3. XM_005168683.5 → XP_005168740.1  adenylate kinase isoenzyme 1 isoform X1

      See identical proteins and their annotated locations for XP_005168740.1

      UniProtKB/TrEMBL
      A0A8M2BGJ7, B2GNJ2, F6PFH0, Q68EH2
      Conserved Domains (2) summary
      TIGR01360
      Location:6 → 193
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:10 → 182
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    4. XM_009302056.4 → XP_009300331.1  adenylate kinase isoenzyme 1 isoform X1

      See identical proteins and their annotated locations for XP_009300331.1

      UniProtKB/TrEMBL
      A0A8M2BGJ7, B2GNJ2, F6PFH0, Q68EH2
      Related
      ENSDARP00000155560.1, ENSDART00000187767.1
      Conserved Domains (2) summary
      TIGR01360
      Location:6 → 193
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:10 → 182
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    Nucleotide Protein
    Heading Accession and Version

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