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    arl4aa ADP-ribosylation factor-like 4aa [ Danio rerio (zebrafish) ]

    Gene ID: 393834, updated on 27-Dec-2024

    Summary

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    Official Symbol
    arl4aaprovided by ZNC
    Official Full Name
    ADP-ribosylation factor-like 4aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1878
    See related
    Ensembl:ENSDARG00000099918 AllianceGenome:ZFIN:ZDB-GENE-040426-1878
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    arl4; arl4a; zgc:56468; zgc:77800
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including cardiovascular system; hematopoietic system; mesoderm; nervous system; and pleuroperitoneal region. Orthologous to human ARL4A (ARF like GTPase 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arl4aa in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (34069800..34074979)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (34211821..34217000)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene Schwann cell-specific EGF-like repeat autocrine factor Neighboring gene von Willebrand factor D and EGF domains Neighboring gene si:dkey-30e9.6 Neighboring gene ETS variant transcription factor 1 Neighboring gene diacylglycerol kinase, beta Neighboring gene uncharacterized LOC137487770

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium. Guo Y, et al. Stem Cell Reports, 2020 Apr 14. PMID 32220330, Free PMC Article
    2. Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Cannon JE, et al. Mech Dev, 2013 Feb. PMID 23072875, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium.
      Title: Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC77800

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like 4aa
    Names
    ADP-ribosylation factor-like 4
    ADP-ribosylation factor-like 4a
    NP_957154.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200860.1 → NP_957154.1  ADP-ribosylation factor-like 4aa

      See identical proteins and their annotated locations for NP_957154.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062856
      UniProtKB/TrEMBL
      A0A8M1PI23, Q6P5K1
      Related
      ENSDARP00000141503.1, ENSDART00000163513.2
      Conserved Domains (2) summary
      cd04152
      Location:20 → 193
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
      COG1100
      Location:17 → 162
      Gem1; GTPase SAR1 family domain [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      34069800..34074979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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