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    cbx1b chromobox homolog 1b (HP1 beta homolog Drosophila) [ Danio rerio (zebrafish) ]

    Gene ID: 415180, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cbx1bprovided by ZNC
    Official Full Name
    chromobox homolog 1b (HP1 beta homolog Drosophila)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-68
    See related
    Ensembl:ENSDARG00000054442 AllianceGenome:ZFIN:ZDB-GENE-040625-68
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:86924
    Summary
    Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in heterochromatin formation. Predicted to be located in pericentric heterochromatin. Orthologous to human CBX1 (chromobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cbx1b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (28870462..28881662, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (28755560..28766779, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene si:ch211-194k22.8 Neighboring gene nfe2 like bZIP transcription factor 1b Neighboring gene phosphorylase kinase, gamma 2 (testis) Neighboring gene cilia and flagella associated protein 119 Neighboring gene ring finger protein 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Repertoire of protein kinases encoded in the genome of zebrafish shows remarkably large population of PIM kinases. Rakshambikai R, et al. J Bioinform Comput Biol, 2014 Feb. PMID 24467753
    2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pericentric heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chromobox protein homolog 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002090.1 → NP_001002090.1  chromobox protein homolog 1b

      See identical proteins and their annotated locations for NP_001002090.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071539
      UniProtKB/TrEMBL
      A0A8M2B288, Q6IQ71
      Related
      ENSDARP00000113004.1, ENSDART00000136593.3
      Conserved Domains (2) summary
      pfam00385
      Location:54 → 97
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      pfam01393
      Location:136 → 187
      Chromo_shadow; Chromo shadow domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      28870462..28881662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156238.5 → XP_005156295.1  chromobox protein homolog 1b isoform X2

      UniProtKB/TrEMBL
      A0A8M2B2K9
      Conserved Domains (2) summary
      pfam00385
      Location:53 → 96
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      pfam01393
      Location:135 → 186
      Chromo_shadow; Chromo shadow domain

    2. XM_005156237.5 → XP_005156294.1  chromobox protein homolog 1b isoform X1

      See identical proteins and their annotated locations for XP_005156294.1

      UniProtKB/TrEMBL
      A0A8M2B288, Q6IQ71
      Conserved Domains (2) summary
      pfam00385
      Location:54 → 97
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      pfam01393
      Location:136 → 187
      Chromo_shadow; Chromo shadow domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394848.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      312939..314036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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