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    bik BCL2 interacting killer [ Danio rerio (zebrafish) ]

    Gene ID: 564030, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bikprovided by ZNC
    Official Full Name
    BCL2 interacting killerprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041210-181
    See related
    Ensembl:ENSDARG00000045549 AllianceGenome:ZFIN:ZDB-GENE-041210-181
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-31f5.6
    Summary
    Acts upstream of or within positive regulation of apoptotic process. Predicted to be located in membrane. Is expressed in eye; gut; kidney; ovary; and trunk. Human ortholog(s) of this gene implicated in ataxia telangiectasia; breast cancer; colon cancer; and prostate cancer. Orthologous to human BIK (BCL2 interacting killer). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bik in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (18843076..18846611)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (18854010..18857635)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110439362 Neighboring gene solute carrier family 26 member 3 Neighboring gene Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial) Neighboring gene RAP1B, member of RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Reproductive parameters of double transgenic zebrafish (Danio rerio) males overexpressing both the growth hormone (GH) and its receptor (GHR). Silva AC, et al. Transgenic Res, 2017 Feb. PMID 27743222
    2. Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish. Gjini E, et al. Dis Model Mech, 2019 May 7. PMID 31064769, Free PMC Article
    3. A structural investigation of NRZ mediated apoptosis regulation in zebrafish. Suraweera CD, et al. Cell Death Dis, 2018 Sep 20. PMID 30237469, Free PMC Article
    4. Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis. Wang J, et al. Cell Death Dis, 2021 Jun 30. PMID 34193827, Free PMC Article
    5. Paternal exposure to environmental 17-alpha-ethinylestradiol concentrations modifies testicular transcription, affecting the sperm transcript content and the offspring performance in zebrafish. Valcarce DG, et al. Aquat Toxicol, 2017 Dec. PMID 29028550

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bcl-2-interacting killer
    Names
    BCL2-interacting killer (apoptosis-inducing)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045038.2 → NP_001038503.2  bcl-2-interacting killer

      See identical proteins and their annotated locations for NP_001038503.2

      Status: PROVISIONAL

      Source sequence(s)
      DQ860154
      UniProtKB/TrEMBL
      A4IGD7, Q5RGV6
      Related
      ENSDARP00000066976.5, ENSDART00000066977.7
      Conserved Domains (1) summary
      pfam06393
      Location:14 → 51
      BID; BH3 interacting domain (BID)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      18843076..18846611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164756.2 → XP_005164813.1  bcl-2-interacting killer isoform X1

      UniProtKB/TrEMBL
      A0A8M2BBX8, Q5RGV7
      Related
      ENSDARP00000117518.1, ENSDART00000132567.2
      Conserved Domains (1) summary
      pfam06393
      Location:14 → 51
      BID; BH3 interacting domain (BID)
    Nucleotide Protein
    Heading Accession and Version

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