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    cyp11c1 cytochrome P450, family 11, subfamily C, polypeptide 1 [ Danio rerio (zebrafish) ]

    Gene ID: 791124, updated on 15-Dec-2024

    Summary

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    Official Symbol
    cyp11c1provided by ZNC
    Official Full Name
    cytochrome P450, family 11, subfamily C, polypeptide 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070828-1
    See related
    Ensembl:ENSDARG00000042014 AllianceGenome:ZFIN:ZDB-GENE-070828-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cyp11b2
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and steroid 11-beta-monooxygenase activity. Acts upstream of or within cortisol metabolic process; male gonad development; and mating behavior. Predicted to be located in membrane and synapse. Predicted to be active in mitochondrial inner membrane. Is expressed in Leydig cell; brain; and pleuroperitoneal region. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cyp11c1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (54459131..54471295, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (54639247..54653906, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Neighboring gene pyruvate kinase L/R Neighboring gene CDC-like kinase 2b Neighboring gene cAMP responsive element binding protein 3-like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Lycium barbarum polysaccharide alleviates nonylphenol exposure induced testicular injury in juvenile zebrafish. Tang ZY, et al. Int J Biol Macromol, 2017 Nov. PMID 28636878
    2. Physiological roles of glucocorticoids during early embryonic development of the zebrafish (Danio rerio). Wilson KS, et al. J Physiol, 2013 Dec 15. PMID 24167225, Free PMC Article
    3. Environmental level of the antidepressant venlafaxine induces behavioral disorders through cortisol in zebrafish larvae (Danio rerio). Tang Y, et al. Neurotoxicol Teratol, 2021 Jan-Feb. PMID 33220437
    4. Anti-Müllerian hormone and 11 beta-hydroxylase show reciprocal expression to that of aromatase in the transforming gonad of zebrafish males. Wang XG, et al. Dev Dyn, 2007 May. PMID 17393497
    5. Localization of steroidogenic enzymes and Foxl2a in the gonads of mature zebrafish (Danio rerio). Caulier M, et al. Comp Biochem Physiol A Mol Integr Physiol, 2015 Oct. PMID 26099948

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction.
      Title: Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction.
    2. Data show that cytochrome P450 enzymes Cyp17-I, Cyp11c1, Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein Foxl2a were detected both in the testis and ovary.
      Title: Localization of steroidogenic enzymes and Foxl2a in the gonads of mature zebrafish (Danio rerio).
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steroid 11-beta-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cortisol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 11C1
    Names
    cyp11b
    cytochrome P450, family 11, subfamily B, polypeptide 2
    cytochrome P45011B
    NP_001073673.1
    XP_017206857.1
    XP_021322434.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080204.1 → NP_001073673.1  cytochrome P450 11C1

      See identical proteins and their annotated locations for NP_001073673.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ650710
      UniProtKB/TrEMBL
      A0A8M1NCP3, A1XRK1
      Related
      ENSDARP00000150599.1, ENSDART00000185978.1
      Conserved Domains (1) summary
      pfam00067
      Location:43 → 511
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      54459131..54471295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466759.2 → XP_021322434.1  cytochrome P450 11C1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PD87
      Conserved Domains (2) summary
      pfam00067
      Location:225 → 693
      p450; Cytochrome P450
      pfam05835
      Location:1 → 125
      Synaphin; Synaphin protein

    2. XM_017351368.3 → XP_017206857.1  cytochrome P450 11C1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YV96
      Related
      ENSDARP00000061571.5, ENSDART00000061572.6
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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