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    zdhhc18a zinc finger DHHC-type palmitoyltransferase 18a [ Danio rerio (zebrafish) ]

    Gene ID: 564062, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zdhhc18aprovided by ZNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 18aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-424
    See related
    Ensembl:ENSDARG00000069807 AllianceGenome:ZFIN:ZDB-GENE-060929-424
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zdhhc18; zgc:153461
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in negative regulation of innate immune response and protein targeting to membrane. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC18 (zinc finger DHHC-type palmitoyltransferase 18). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See zdhhc18a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (33992385..34006602)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (34038304..34052305)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene AT-rich interaction domain 1Aa Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class V Neighboring gene terminal nucleotidyltransferase 5ba Neighboring gene transcription elongation factor A (SII), 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Wang C, et al. Neurotoxicol Teratol, 2015 Jul-Aug. PMID 26056731
    2. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153461

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC18a
    Names
    zinc finger DHHC-type containing 18a
    zinc finger, DHHC-type containing 18
    NP_001071031.1
    XP_005158417.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077563.1 → NP_001071031.1  palmitoyltransferase ZDHHC18a

      See identical proteins and their annotated locations for NP_001071031.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124360
      UniProtKB/Swiss-Prot
      E7FH11, F1Q6I2, Q08C71
      Related
      ENSDARP00000092660.4, ENSDART00000101885.6
      Conserved Domains (1) summary
      pfam01529
      Location:160 → 284
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      33992385..34006602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158360.5 → XP_005158417.1  palmitoyltransferase ZDHHC18a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B4S0
      Conserved Domains (1) summary
      pfam01529
      Location:160 → 284
      zf-DHHC; DHHC palmitoyltransferase

    RNA

    1. XR_011006578.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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