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    ppiaa peptidylprolyl isomerase Aa (cyclophilin A) [ Danio rerio (zebrafish) ]

    Gene ID: 336612, updated on 15-Dec-2024

    Summary

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    Official Symbol
    ppiaaprovided by ZNC
    Official Full Name
    peptidylprolyl isomerase Aa (cyclophilin A)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8556
    See related
    Ensembl:ENSDARG00000009212 AllianceGenome:ZFIN:ZDB-GENE-030131-8556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Cyp1; ppia; PPIA-2; fa93g09; wu:fa93g09; wu:fb05e11; wu:fb13h02; wu:fb15a05
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to act upstream of or within apoptotic process and protein peptidyl-prolyl isomerization. Predicted to be located in extracellular region. Predicted to be active in mitochondrion and nucleus. Is expressed in adipose tissue; cerebellum; digestive system; eye; and midbrain. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppiaa in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (45755639..45760087, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (45747764..45752178, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 18 member A1 Neighboring gene dickkopf-related protein 4-like Neighboring gene oxoglutarate dehydrogenase a Neighboring gene ADAM metallopeptidase domain 9a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Developmental effects of aerosols and coal burning particles in zebrafish embryos. Olivares A, et al. Environ Pollut, 2013 Jul. PMID 23542445
    2. Detoxification of sewage sludge by natural attenuation and implications for its use as a fertilizer on agricultural soils. Mazzeo DEC, et al. Sci Total Environ, 2016 Dec 1. PMID 27593435
    3. A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development. Jones KS, et al. Nutr Metab (Lond), 2008 Aug 27. PMID 18752667, Free PMC Article
    4. Fatty acid binding proteins have the potential to channel dietary fatty acids into enterocyte nuclei. Esteves A, et al. J Lipid Res, 2016 Feb. PMID 26658423, Free PMC Article
    5. Conserved expression of alternative splicing variants of peroxisomal acyl-CoA oxidase 1 in vertebrates and developmental and nutritional regulation in fish. Morais S, et al. Physiol Genomics, 2007 Feb 12. PMID 17090698

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase A
    Names
    peptidylprolyl isomerase A (cyclophilin A)
    NP_997923.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212758.2 → NP_997923.2  peptidyl-prolyl cis-trans isomerase A

      Status: VALIDATED

      Source sequence(s)
      CU137648
      UniProtKB/TrEMBL
      Q6TNR5
      Related
      ENSDARP00000003641.6, ENSDART00000025620.8

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      45755639..45760087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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