chrna1 cholinergic receptor, nicotinic, alpha 1 (muscle) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chrna1provided by ZNC
Official Full Name: cholinergic receptor, nicotinic, alpha 1 (muscle)provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-137
See related: Ensembl:ENSDARG00000009021 AllianceGenome:ZFIN:ZDB-GENE-980526-137
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nic1; zgc:86593
Summary: Enables monoatomic cation channel activity. Contributes to acetylcholine binding activity and acetylcholine receptor activity. Acts upstream of or within several processes, including chemical synaptic transmission; chondrocyte intercalation involved in growth plate cartilage morphogenesis; and skeletal muscle fiber development. Part of acetylcholine-gated channel complex. Is expressed in adaxial cell; musculature system; and somite. Used to study congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 1A and congenital myasthenic syndrome 1B. Orthologous to human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (10812337..10828923, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (10576910..10593496, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to acetylcholine binding	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to acetylcholine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to acetylcholine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine-gated monoatomic cation-selective channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IEA Inferred from Electronic Annotation more info
contributes_to acetylcholine-gated monoatomic cation-selective channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chondrocyte intercalation involved in growth plate cartilage morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane depolarization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within membrane repolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuromuscular synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within receptor clustering	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, cholinergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic transmission, cholinergic	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of acetylcholine-gated channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of acetylcholine-gated channel complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acetylcholine receptor subunit alpha

Names: AChR alpha 1; cholinergic receptor, nicotinic, alpha polypeptide 1; nic; nic-1; nicotinic acetylcholine receptor alpha-1; nicotinic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131445.1 → NP_571520.1 acetylcholine receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_571520.1

Status: PROVISIONAL

Source sequence(s)

U70438

UniProtKB/Swiss-Prot

Q98880

Related

ENSDARP00000021860.6, ENSDART00000020261.8

Conserved Domains (3) summary

TIGR00860
Location:21 → 447

LIC; Cation transporter family protein

pfam02931
Location:24 → 231

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:238 → 446

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region