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    septin12 septin 12 [ Danio rerio (zebrafish) ]

    Gene ID: 564600, updated on 9-Dec-2024

    Summary

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    Official Symbol
    septin12provided by ZNC
    Official Full Name
    septin 12provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120215-68
    See related
    Ensembl:ENSDARG00000019191 AllianceGenome:ZFIN:ZDB-GENE-120215-68
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sept12; si:dkey-23a11.2
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Human ortholog(s) of this gene implicated in spermatogenic failure 10. Orthologous to human SEPTIN12 (septin 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See septin12 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (28502577..28627260)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (28371513..28496418)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 114 Neighboring gene RNA binding fox-1 homolog 1 Neighboring gene uncharacterized LOC137490603 Neighboring gene si:dkey-20j1.2 Neighboring gene uncharacterized LOC137490606 Neighboring gene F-box and leucine-rich repeat protein 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish null mutants of Sept6 and Sept15 are viable but more susceptible to Shigella infection. Torraca V, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 36855298, Free PMC Article
    2. The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. Lv Y, et al. J Biol Chem, 2024 Mar. PMID 38382674, Free PMC Article
    3. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    septin-12; neuronal-specific septin-3; septin-9; uncharacterized protein septin12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      28502577..28627260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299472.4 → XP_009297747.1  uncharacterized protein septin12 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AY11, E7FGH0
      Related
      ENSDARP00000126089.1, ENSDART00000151081.3
      Conserved Domains (2) summary
      cd01850
      Location:523 → 797
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:505 → 800
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    2. XM_005163961.4 → XP_005164018.1  septin-9 isoform X3

      See identical proteins and their annotated locations for XP_005164018.1

      UniProtKB/TrEMBL
      A0A8M2BB45, I3ISV7
      Conserved Domains (2) summary
      cd01850
      Location:56 → 330
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:38 → 333
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    3. XM_005163960.5 → XP_005164017.1  septin-9 isoform X3

      See identical proteins and their annotated locations for XP_005164017.1

      UniProtKB/TrEMBL
      A0A8M2BB45, I3ISV7
      Related
      ENSDARP00000126002.1, ENSDART00000151189.3
      Conserved Domains (2) summary
      cd01850
      Location:56 → 330
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:38 → 333
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    4. XM_687930.6 → XP_693022.3  neuronal-specific septin-3 isoform X2

      UniProtKB/TrEMBL
      A0A8N7T7N9
      Conserved Domains (2) summary
      cd01850
      Location:74 → 348
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:56 → 351
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    Nucleotide Protein Strain
    Heading Accession and Version

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