twsg1b twisted gastrulation BMP signaling modulator 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: twsg1bprovided by ZNC
Official Full Name: twisted gastrulation BMP signaling modulator 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020812-3
See related: Ensembl:ENSDARG00000103580 AllianceGenome:ZFIN:ZDB-GENE-020812-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tsg1; tsgb; ztsg1
Summary: Acts upstream of or within several processes, including determination of ventral identity; embryonic hemopoiesis; and positive regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in male organism. Orthologous to human TWSG1 (twisted gastrulation BMP signaling modulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 3, chromosome: 24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (42051712..42052597)
RS_2024_08	current	GRCz11 (GCF_000002035.6)	Unplaced Scaffold	NW_003336973.1 (970..3012)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003336157.1 (4592..5477)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003336973.1 (970..3012)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zebrafish Tsg1 promotes BMP signaling, and thus ventral cell fates, during DV axial patterning
Title: Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of ventral identity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of ventral identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hemopoiesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: twisted gastrulation protein homolog 1-B

Names: twisted gastrulation b; twisted gastrulation homolog 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153672.2 → NP_705958.1 twisted gastrulation protein homolog 1-B precursor

See identical proteins and their annotated locations for NP_705958.1

Status: PROVISIONAL

Source sequence(s)

BC118680

UniProtKB/Swiss-Prot

Q3SYN9, Q98SR9

UniProtKB/TrEMBL

B2GRJ7

Related

ENSDARP00000141810.1, ENSDART00000163779.2

Conserved Domains (1) summary

pfam04668
Location:87 → 221

Tsg; Twisted gastrulation (Tsg) protein conserved region