itgae.2 integrin, alpha E, tandem duplicate 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itgae.2provided by ZNC
Official Full Name: integrin, alpha E, tandem duplicate 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-130530-671
See related: Ensembl:ENSDARG00000057787 AllianceGenome:ZFIN:ZDB-GENE-130530-671
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-24o10.9
Summary: Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be part of integrin complex. Predicted to be active in external side of plasma membrane. Orthologous to human ITGAE (integrin subunit alpha E). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (17170092..17190536, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (17236244..17254516, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of integrin complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin alpha-E

Names: itgae; zmp:0000000668

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

17170092..17190536 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003200028.6 → XP_003200076.2 integrin alpha-E isoform X1

UniProtKB/TrEMBL

A0A8M1RMI4

Related

ENSDARP00000128066.1, ENSDART00000154801.2

Conserved Domains (3) summary

smart00191
Location:540 → 589

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:635 → 922

Integrin_alpha2; Integrin alpha

cl00057
Location:180 → 355

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394943.1 Reference GRCz11 ALT_DRER_TU_1

Range

286963..307407 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021472928.2 → XP_021328603.1 integrin alpha-E isoform X1

UniProtKB/TrEMBL

A0A8M1RMI4

Conserved Domains (3) summary

smart00191
Location:540 → 589

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:635 → 922

Integrin_alpha2; Integrin alpha

cl00057
Location:180 → 355

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Reference GRCz11 ALT_DRER_TU_2

Genomic

NW_018395321.1 Reference GRCz11 ALT_DRER_TU_2

Range

132220..150005 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474336.2 → XP_021330011.1 integrin alpha-E isoform X2

UniProtKB/TrEMBL

A0A8M9Q4X6

Conserved Domains (3) summary

smart00191
Location:242 → 291

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:337 → 627

Integrin_alpha2; Integrin alpha

cl00057
Location:3 → 57

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...