coq8aa coenzyme Q8A, genome duplicate a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: coq8aaprovided by ZNC
Official Full Name: coenzyme Q8A, genome duplicate aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-487
See related: Ensembl:ENSDARG00000020123 AllianceGenome:ZFIN:ZDB-GENE-040718-487
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: adck3; cabc1; coq8a; zgc:92578
Summary: Predicted to enable ADP binding activity and kinase activity. Predicted to be involved in phosphorylation and ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 4. Orthologous to human COQ8A (coenzyme Q8A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (38458084..38519126)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (38555205..38616247)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj35a09.x1 (e-PCR)
- UniSTS:199174

fi42g06.x1 (e-PCR)
- UniSTS:197511

fl04d06.x1 (e-PCR)
- UniSTS:201887

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ADP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
NOT enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: atypical kinase COQ8A, mitochondrial

Names: aarF domain containing kinase 3; aarF domain-containing protein kinase 3; atypical kinase ADCK3, mitochondrial; chaperone activity of bc1 complex-like, mitochondrial; coenzyme Q protein 8A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002728.2 → NP_001002728.2 atypical kinase COQ8A, mitochondrial

See identical proteins and their annotated locations for NP_001002728.2

Status: VALIDATED

Source sequence(s)

BC076083, CB353142, CK000015, CN502119, DY549009, EE705849

UniProtKB/Swiss-Prot

G1K2I4, Q5RGU1, Q6DH95

Related

ENSDARP00000024635.5, ENSDART00000020153.8

Conserved Domains (2) summary

COG0661
Location:172 → 603

AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]

cd13970
Location:264 → 514

ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3