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    guk1b guanylate kinase 1b [ Danio rerio (zebrafish) ]

    Gene ID: 393697, updated on 9-Dec-2024

    Summary

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    Official Symbol
    guk1bprovided by ZNC
    Official Full Name
    guanylate kinase 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020916-1
    See related
    Ensembl:ENSDARG00000005776 AllianceGenome:ZFIN:ZDB-GENE-020916-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    guk1; zgc:73128; zgc:73217
    Summary
    Predicted to enable guanylate kinase activity. Predicted to act upstream of or within phosphorylation and purine nucleotide metabolic process. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in epiphysis; retina; retinal outer nuclear layer; and retinal photoreceptor layer. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See guk1b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (18230948..18340144, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (18195248..18203815, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 8b Neighboring gene mutY DNA glycosylase Neighboring gene ring finger protein 220b Neighboring gene DNA methyltransferase 1 associated protein 1 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa. Yin J, et al. Mol Neurodegener, 2011 Jul 30. PMID 21801444, Free PMC Article
    2. Use of toxicogenomics to predict the potential toxic effect of Benzo(a)pyrene on zebrafish embryos: ocular developmental toxicity. Huang L, et al. Chemosphere, 2014 Aug. PMID 24875912
    3. Cellular expression of Smarca4 (Brg1)-regulated genes in zebrafish retinas. Hensley MR, et al. BMC Dev Biol, 2011 Jul 14. PMID 21756345, Free PMC Article
    4. Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior. Ben-Moshe Livne Z, et al. PLoS Genet, 2016 Nov. PMID 27870848, Free PMC Article
    5. Gene expression profiling of zebrafish embryonic retina. Leung YF, et al. Zebrafish, 2005. PMID 18248185

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC73128

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guanylate kinase 1b
    Names
    guanylate kinase 1
    NP_957018.1
    XP_005166853.1
    XP_068079002.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200724.1 → NP_957018.1  guanylate kinase 1b

      See identical proteins and their annotated locations for NP_957018.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059491
      UniProtKB/TrEMBL
      Q6PC32
      Related
      ENSDARP00000023640.7, ENSDART00000022959.9
      Conserved Domains (2) summary
      TIGR03263
      Location:5 → 213
      guanyl_kin; guanylate kinase
      COG0194
      Location:1 → 219
      Gmk; Guanylate kinase [Nucleotide transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      18230948..18340144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222901.1 → XP_068079002.1  guanylate kinase 1b isoform X1

    2. XM_005166796.4 → XP_005166853.1  guanylate kinase 1b isoform X2

      UniProtKB/TrEMBL
      A0A8M2BEA8, B8JJJ6
      Related
      ENSDARP00000074439.5, ENSDART00000079989.7
      Conserved Domains (2) summary
      TIGR03263
      Location:5 → 187
      guanyl_kin; guanylate kinase
      pfam00625
      Location:3 → 188
      Guanylate_kin; Guanylate kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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