hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsd3b7provided by ZNC
Official Full Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomeraseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5673
See related: Ensembl:ENSDARG00000036966 AllianceGenome:ZFIN:ZDB-GENE-030131-5673
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc37e10; zgc:55799; wu:fc37e10; wu:fi12g10
Summary: Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to act upstream of or within steroid biosynthetic process. Is expressed in several structures, including adenohypophysis; digestive system; lens; macrophage; and solid lens vesicle. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 1 and intrahepatic cholestasis. Orthologous to human HSD3B7 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (32749693..32778247)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (32612001..32646537)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: 3 beta-hydroxysteroid dehydrogenase type 7

Names: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

NP_956103.1

EC 1.1.1.181

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199809.1 → NP_956103.1 3 beta-hydroxysteroid dehydrogenase type 7

See identical proteins and their annotated locations for NP_956103.1

Status: PROVISIONAL

Source sequence(s)

BC045457

UniProtKB/TrEMBL

A0A8M3AY18, F1QEV3, Q7ZVQ1

Related

ENSDARP00000053683.5, ENSDART00000053684.7

Conserved Domains (2) summary

pfam01073
Location:12 → 286

3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family

cl21454
Location:11 → 356

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins