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    GSTM5 glutathione S-transferase mu 5 [ Homo sapiens (human) ]

    Gene ID: 2949, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GSTM5provided by HGNC
    Official Full Name
    glutathione S-transferase mu 5provided by HGNC
    Primary source
    HGNC:HGNC:4637
    See related
    Ensembl:ENSG00000134201 MIM:138385; AllianceGenome:HGNC:4637
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GTM5; GSTM5-5
    Summary
    Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in ovary (RPKM 81.4), gall bladder (RPKM 13.9) and 9 other tissues See more
    Orthologs
    all
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    Genomic context

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    See GSTM5 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (109711751..109718268)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (109721793..109728310)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110254873..110260890)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1450 Neighboring gene glutathione S-transferase mu 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1451 Neighboring gene glutathione S-transferase mu 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1158 Neighboring gene glutathione S-transferase mu 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:110293035-110294234 Neighboring gene EPS8 signaling adaptor L3 Neighboring gene uncharacterized LOC124904258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110303188-110303917

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Anti-Cancer Effects and Tumor Marker Role of Glutathione S-Transferase Mu 5 in Human Bladder Cancer. Jou YC, et al. Int J Mol Sci, 2021 Mar 17. PMID 33802702, Free PMC Article
    2. Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis. Hao X, et al. BMC Cancer, 2022 Jun 21. PMID 35729618, Free PMC Article
    3. GSTM1 and GSTM5 Genetic Polymorphisms and Expression in Age-Related Macular Degeneration. Hunter AA 3rd, et al. Curr Eye Res, 2016. PMID 25897651, Free PMC Article
    4. A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5. Takahashi Y, et al. J Biol Chem, 1993 Apr 25. PMID 8473333
    5. Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera. Rowe JD, et al. Biochem J, 1997 Jul 15. PMID 9230131, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis.
      Title: Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis.
    2. Anti-Cancer Effects and Tumor Marker Role of Glutathione S-Transferase Mu 5 in Human Bladder Cancer.
      Title: Anti-Cancer Effects and Tumor Marker Role of Glutathione S-Transferase Mu 5 in Human Bladder Cancer.
    3. Genomic polymorphisms of GSTM1 and GSTM5 do not significantly affect the peripheral blood leukocyte mRNA levels.
      Title: GSTM1 and GSTM5 Genetic Polymorphisms and Expression in Age-Related Macular Degeneration.
    4. The evidence presented suggests that GSTM1 and GSTM5 undergo epigenetic repression in AMD RPE/choroid, which may increase susceptibility to oxidative stress in AMD retinas.
      Title: DNA methylation is associated with altered gene expression in AMD.
    5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase Mu 5
    Names
    GST class-mu 5
    S-(hydroxyalkyl)glutathione lyase M5
    epididymis secretory sperm binding protein
    glutathione S-alkyltransferase M5
    glutathione S-aralkyltransferase M5
    glutathione S-aryltransferase M5
    glutathione S-transferase M5
    NP_000842.2
    XP_005270841.1
    XP_005270842.1
    XP_054192143.1
    XP_054192144.1
    XP_054192145.1
    XP_054192146.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000851.4 → NP_000842.2  glutathione S-transferase Mu 5

      See identical proteins and their annotated locations for NP_000842.2

      Status: REVIEWED

      Source sequence(s)
      AC000032, BC058881, BX281326, DB089682
      Consensus CDS
      CCDS811.1
      UniProtKB/Swiss-Prot
      A8K0V8, P46439, Q6PD78
      UniProtKB/TrEMBL
      A0A3B3IRM5, Q5T8R2
      Related
      ENSP00000256593.3, ENST00000256593.8
      Conserved Domains (2) summary
      cd03209
      Location:92 → 212
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:3 → 84
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      109711751..109718268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005270784.5 → XP_005270841.1  glutathione S-transferase Mu 5 isoform X1

      See identical proteins and their annotated locations for XP_005270841.1

      UniProtKB/Swiss-Prot
      A8K0V8, P46439, Q6PD78
      UniProtKB/TrEMBL
      A0A3B3IRM5, Q5T8R2
      Related
      ENSP00000496849.1, ENST00000647711.1
      Conserved Domains (2) summary
      cd03209
      Location:92 → 212
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:3 → 84
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    2. XM_005270785.5 → XP_005270842.1  glutathione S-transferase Mu 5 isoform X2

      Conserved Domains (1) summary
      cl02776
      Location:1 → 108
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      109721793..109728310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336168.1 → XP_054192143.1  glutathione S-transferase Mu 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K0V8, P46439, Q6PD78
      UniProtKB/TrEMBL
      A0A3B3IRM5, Q5T8R2

    2. XM_054336169.1 → XP_054192144.1  glutathione S-transferase Mu 5 isoform X3

      UniProtKB/TrEMBL
      A0A3B3IRM5, Q5T8R1

    3. XM_054336170.1 → XP_054192145.1  glutathione S-transferase Mu 5 isoform X2

    4. XM_054336171.1 → XP_054192146.1  glutathione S-transferase Mu 5 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46439.3 GenPept UniProtKB/Swiss-Prot:P46439

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