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    nfeF NADPH-dependent ferric-chelate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947582, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nfeF
    Official Full Name
    NADPH-dependent ferric-chelate reductase
    Primary source
    ECOCYC:G7593
    Locus tag
    b3070
    See related
    ASAP:ABE-0010079
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3060; yqjH
    Summary
    Expression of yqjH may be regulated by Fur; a candidate FUR box has been found upstream of the ORF . [More information is available at EcoCyc: G7593].
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    Genomic context

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    Sequence:
    NC_000913.3 (3215727..3216491, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene stationary phase mismatch/uracil DNA glycosylase Neighboring gene tRNA-Ile Neighboring gene DNA-binding transcriptional repressor NfeR Neighboring gene aerotaxis receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli. Miethke M, et al. Biochemistry, 2011 Dec 20. PMID 22098718
    2. Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative cytoplasmic ferri-siderophore reductase. Bamford VA, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Sep 1. PMID 18765906, Free PMC Article
    3. Comparative analysis of FUR regulons in gamma-proteobacteria. Panina EM, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812853, Free PMC Article
    4. Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli. Wang S, et al. J Bacteriol, 2011 Jan. PMID 21097627, Free PMC Article
    5. Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasis. McHugh JP, et al. J Biol Chem, 2003 Aug 8. PMID 12746439

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Site-directed mutagenesis reveals that residues K55 and R130 are crucial for substrate binding and ferric reductase activity. Catalytic/structural analysis: substrate specificity, kinetic analysis, reaction mechanism, amino acid sequence alignment.
      Title: The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli.
    2. The authors show that YqjH has ferric reductase activity and is required for iron homeostasis in Escherichia coli.
      Title: Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    NADPH-dependent ferric-chelate reductase
    NP_417541.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3215727..3216491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417541.1 NADPH-dependent ferric-chelate reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417541.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N0IM67
      Conserved Domains (1) summary
      COG2375
      Location:1 → 254
      ViuB; NADPH-dependent ferric siderophore reductase, contains FAD-binding and SIP domains [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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