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    recF recombination mediator protein RecF [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948209, updated on 17-Dec-2024

    Summary

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    Official Symbol
    recF
    Official Full Name
    recombination mediator protein RecF
    Primary source
    ECOCYC:EG10828
    Locus tag
    b3700
    See related
    ASAP:ABE-0012095
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3692; uvrF
    Summary
    [More information is available at EcoCyc: EG10828].
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    Genomic context

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    Sequence:
    NC_000913.3 (3880148..3881221, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF937 domain-containing protein YidB Neighboring gene DNA gyrase subunit B Neighboring gene beta sliding clamp Neighboring gene chromosomal replication initiator protein DnaA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RecF pathway of homologous recombination can mediate the initiation of DNA damage-inducible replication of the Escherichia coli chromosome. Asai T, et al. J Bacteriol, 1994 Nov. PMID 7961480, Free PMC Article
    2. Gene conversion in the Escherichia coli RecF pathway: a successive half crossing-over model. Yamamoto K, et al. Mol Gen Genet, 1992 Jul. PMID 1495473
    3. Sequence and complementation analysis of recF genes from Escherichia coli, Salmonella typhimurium, Pseudomonas putida and Bacillus subtilis: evidence for an essential phosphate binding loop. Sandler SJ, et al. Nucleic Acids Res, 1992 Feb 25. PMID 1542576, Free PMC Article
    4. Analysis of involvement of the RecF pathway in p44 recombination in Anaplasma phagocytophilum and in Escherichia coli by using a plasmid carrying the p44 expression and p44 donor loci. Lin Q, et al. Infect Immun, 2006 Apr. PMID 16552034, Free PMC Article
    5. DNA repair: common approaches to fixing double-strand breaks. Hiom K. Curr Biol, 2009 Jul 14. PMID 19602417

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RecF protein targeting to postreplication (daughter strand) gaps I: DNA binding by RecF and RecFR.
      Title: RecF protein targeting to postreplication (daughter strand) gaps I: DNA binding by RecF and RecFR.
    2. RecF protein targeting to post-replication (daughter strand) gaps II: RecF interaction with replisomes.
      Title: RecF protein targeting to post-replication (daughter strand) gaps II: RecF interaction with replisomes.
    3. The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ.
      Title: The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ.
    4. we used genetics and single-molecule fluorescence microscopy to investigate whether RecF and RecO function together, or separately, in live Escherichia coli cells. We identified conditions in which RecF and RecO functions are genetically separable.
      Title: RecFOR epistasis group: RecF and RecO have distinct localizations and functions in Escherichia coli.
    5. model in which the recA433 mutation selectively impairs RecA functions associated with the RecF pathway, while retaining the ability to carry out RecBCD pathway-mediated functions
      Title: RecA433 cells are defective in recF-mediated processing of disrupted replication forks but retain recBCD-mediated functions.
    6. Data show that UvrD and UvrD252 counteract RecQ, RecJ, and RecFOR at forks blocked in the rep mutant of Escherichia coli.
      Title: UvrD and UvrD252 counteract RecQ, RecJ, and RecFOR in a rep mutant of Escherichia coli.
    7. N-terminus verified by Edman degradation on mature peptide
      Title: Purification and preliminary characterization of the Escherichia coli K-12 recF protein.
    8. Our results suggest that two types of sbcB-sensitive RecF pathways can be distinguished in E. coli, one that is activated by the sbcB15 mutation and one that is activated by sbcB null mutations.
      Title: sbcB15 And DeltasbcB mutations activate two types of recf recombination pathways in Escherichia coli.
    9. the RecF sub-pathways accounting for about 2/3 of the recombinants in E.coli
      Title: Inactivation of recG stimulates the RecF pathway during lesion-induced recombination in E. coli.
    10. A p44 recombination intermediate of Anaplasma phagocytophila is recovered in an E. coli strain with active RecF recombination pathway but not in strains with deficient RecF pathway.
      Title: Analysis of involvement of the RecF pathway in p44 recombination in Anaplasma phagocytophilum and in Escherichia coli by using a plasmid carrying the p44 expression and p44 donor loci.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA synthesis involved in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA synthesis involved in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SOS response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in recombinational repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in recombinational repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to UV EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    recombination mediator protein RecF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3880148..3881221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418155.1 recombination mediator protein RecF [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418155.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376Y026
      Conserved Domains (1) summary
      TIGR00611
      Location:1 → 355
      recf; recF protein
    Nucleotide Protein
    Heading Accession and Version

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